NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases

Launched by ADIR ASSOCIATION · Dec 13, 2023

Keywords

ClinConnect Summary

This clinical trial is designed to compare two types of treatments for patients experiencing severe breathing problems due to acute exacerbations of interstitial lung disease, a condition that affects the lung tissue. Specifically, the study will look at how high-flow oxygen therapy and noninvasive mechanical ventilation (a method that helps patients breathe without needing a breathing tube) affect breathing, effort required to breathe, and blood circulation during these critical moments.

To qualify for this trial, participants must be over 18 years old, currently hospitalized in an intensive care unit, and have experienced worsening shortness of breath for at least a month. They should also have specific lung changes visible on a CT scan and need extra oxygen support. However, certain individuals, such as those with serious heart problems, obesity, or certain medical devices, will not be eligible to participate. If enrolled, participants can expect to receive either of the two treatments while the research team closely monitors their breathing and overall health. This study aims to find out which treatment might work better for patients in this challenging situation.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • Age \> 18 yrs
• • Hospitalization in intensive care unit
• • Acute exacerbation of a previously/presently documented diffuse (fibrotic) interstitial lung disease
• • Dyspnea majoration since at least 1 month
• • Alveolar or ground-glass opacities on CT-scan that are superposed to interstitial lung disease and not explained by left heart failure or volume overload
• • Hypoxemia requiring oxygen flows \> 6 L/min
• Exclusion criteria:
• • Contraindication to noninvasive ventilation or high-flow oxygen therapy
• • Immediate indication to endotracheal intubation or hemodynamic assistance
• • Body mass index \> 40
• • Presence of a pacemaker or an implantable defibrillator
• • Presence of cutaneous lesions where Pulmovista® belt should be placed
• • Moribund patient
• • Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception
• • Protected adult patient (tutorship or curatorship)
• • Patient deprived of liberty by court or administrative decision
• • No possibility to install nasogastric tube
• • Endotracheal or tracheostomy tube requirement during the study
• • Hemodynamic assistance requirement during the study