Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Dec 14, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how radiation therapy, which is a common treatment for brain tumors in children and young adults, affects the brain's ability to function, particularly in areas responsible for thinking and memory. Researchers want to understand how changes in brain networks after treatment might lead to difficulties in thinking and learning, which can impact a patient’s ability to live independently. By using advanced imaging techniques, the study aims to identify specific changes in the brain based on the amount of radiation received.

To participate in this study, individuals need to be between 8 and 21 years old and have a newly diagnosed primary brain tumor that will be treated with a type of radiation called proton therapy. They also need to be able to understand the study and agree to participate, with help from a parent or guardian if required. Participants will undergo brain imaging before and after their treatment to help researchers gather important information about how radiation impacts brain function. This study is currently recruiting participants, and taking part could help improve understanding of cognitive challenges faced by young brain tumor survivors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Between 8 and 21 years of age, inclusive
• • Newly diagnosed primary brain tumor of any location and any histology that will be treated with proton radiation therapy
• • Life expectancy of at least one year
• • Able to understand and willing to consent or assent to the research proposed (or that of a legally authorized representative, if applicable), along with consent of legal guardian(s) if applicable
• Exclusion Criteria:
• • Presence of visual impairment to an extent that the patient is unable to complete the computer testing
• • Contraindication to MRI scan (i.e. due to cardiac pacemaker)
• • Presence of programmable shunt or dental braces
• • Requires sedation for MRI scans