Impact of Skeletal Muscle Quality and Loss on the Outcome of Liver Transplantation

Launched by ZHEJIANG UNIVERSITY · Dec 17, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how the quality and amount of muscle in patients might affect their recovery after a liver transplant. Researchers have found that good muscle health before and after the transplant can influence how well the surgery goes and how patients recover. In this study, they will collect medical images of patients' muscles before and after their liver transplants to better understand this relationship. The goal is to find ways to help doctors monitor patients' health and improve their outcomes after surgery.

To participate in this trial, you need to be an adult who is having a liver transplant from a deceased donor for the first time. Unfortunately, some patients won’t be eligible, including those with certain complications like serious heart or kidney problems, or those who have had previous transplants. If you join the study, you can expect to have CT scans taken of your muscles before and at specific times after your transplant to help researchers gather important information. This research could lead to better care and support for future liver transplant patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients undergoing deceased donor liver transplantation (DDLT) for the first time
• Exclusion Criteria:
• • Pediatric transplants
• • Presence of portal vein tumor thrombus according to imageing before transplantation
• • Presence of macrovascular invasion according to imageing before transplantation
• • Re-transplants
• • Multi-organ transplants
• • Patients who died within 30 days after transplantation
• • Patients diagnosed with skeletal muscle diseases (e.g. muscle atrophy)
• • Patients with serious medical conditions such as heart failure, persistent infection, and renal insufficiency.