Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder

Launched by INSTITUTO NACIONAL DE PSIQUIATRÍA DR. RAMÓN DE LA FUENTE · Dec 19, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a treatment called high-frequency repetitive Transcranial Magnetic Stimulation (HF rTMS) on people with cocaine use disorder. The researchers want to see how this treatment affects brain health, craving for cocaine, and cognitive (thinking) abilities. The trial includes 20 sessions of rTMS followed by another 12 weeks of treatment, where participants will be assessed at the beginning, after the first 20 sessions, and after the 12-week follow-up. Blood tests will be done to measure a specific protein related to brain health, and participants will also complete tests to evaluate their thinking skills.

To participate, individuals should have a current cocaine use disorder and have been using cocaine for at least a year. They should have some basic education and meet specific health criteria to ensure safety during the treatment. However, those with certain neurological conditions, serious heart problems, or a history of seizures are not eligible. Participants will be closely monitored throughout the study, and their feedback will help researchers understand whether this treatment can help reduce cravings and improve cognitive function in people with cocaine dependence.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Current cocaine use disorder according to the Diagnostic and statistical manual of mental disorders (DSM 5).
• • 2. Cocaine crack or powder use for at least 12 months with a frequency of 3 times or more per week, with abstinence periods shorter than 1 year for the last year.
• • 3. Primary school completed.
• Exclusion Criteria:
• • 1. Personal or first degree family history of any neurological disorder including, but not limited to, organic brain syndrome, epilepsy, brain injuries, multiple sclerosis, conditions that increase intracranial pressure.
• • 2. Personal history of brain surgery or traumatic brain injury.
• • 3. Comorbilities that could represent a risk of neuroinfection or increased convulsive threshoid.
• • 4. Other than alcohol, tobacco or marijuana substance use disorder.
• • 5. If the patient does not meet the safety criteria for rTMS.
• • 6. Current use of any medication that might provoque seizures or any anticonvulsant drugs.
• • 7. Personal history of schizophrenia, mania/hypomania or OCD.
• • 8. Personal history of myocardial infarction, angina, congestive heart failure, cerebrovascular events, transient ischemic attack or any other heart condition currently undergoing medical treatment.
• • 9. Personal history of seizures or detection of paroxysmal EEG activity.