Whole Blood Transcriptomic Signal According to Coronary Atherosclerotic Plaque Burden Assessed by CT Angiography

Launched by MULTIPLAI HEALTH LIMITED · Jan 4, 2024

Keywords

ClinConnect Summary

This will be a prospective observational study. A convenience sample will be carried out to include 200 patients who attend the ENERI Medical Institute, La Sagrada Familia Clinic and Sanatorio Mendez with a clinical indication to be evaluated by a CCTA due to suspected CAD or known CAD. The study will have a baseline stage in which a clinical evaluation will be performed, blood samples will be drawn for transcriptome analysis and laboratory analysis. Then, a DNA sample obtained by swabbing the buccal mucose will be taken. Subsequently, the images obtained from the clinically indicated CCTA ...

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Eligibility criteria

• Inclusion Criteria:
• • Men and women between 18 and 75 years, with a clinical indication to be evaluated by a CCTA due to suspected or known CAD.
• • Signature of informed consent.
• Exclusion Criteria:
• • Previously known chronic renal or hepatic insufficiency.
• • Active chronic lung disease, defined as: exacerbated asthma, exacerbated COPD, or pulmonary fibrosis.
• • Myocardial infarction, unstable angina, cerebrovascular accident, or vascular interventions (any territory) in the past 6 months.
• • Implantation of drug-eluting stents in the last 12 months.
• • Revascularization surgery (By-pass)
• • Indication of Angio-CT for congenital heart disease or Transcatheter Aortic Valve Replacement (TAVI)
• • Presence/ diagnosis of heart failure symptoms or signs (ie. dyspnea, asthenia, edema) with objective evidence of pulmonary or systemic congestion at rest or with exercise in the last 6 months.
• • Left ventricular ejection fraction \<50% confirmed by objective diagnostic methods (eg doppler echocardiogram).
• • Severe valvulopathies, confirmed by objective diagnostic methods (eg doppler echocardiogram).
• • Uncontrolled hyper or hypothyroidism.
• • Suprarenal insufficiency.
• • Previous surgeries in the last 3 months.
• • Severe trauma in the last 6 months, defined as one that involved bone fractures and/or surgical interventions.
• • Known active cancer disease or under treatment (acute or preventive), or history of cancer disease without criteria for cure.
• • Diagnosis of active autoimmune disease or any pathology under immunosuppressive treatment.
• • Ongoing pregnancy, postpartum period of less than 12 months or breastfeeding.
• • Other serious diseases with an estimated life expectancy of less than 12 months (according to the investigator's opinion).
• • Temperature greater than 37.5°C recorded by a thermometer or any acute infection caused by viruses or bacteria confirmed by a health professional in the previous 30 days.
• • Pacemaker/Cardio-Defibrillator Implantation.
• • Prior to the study: heart rate \> 70 l/m or atrial fibrillation or frequent extrasystoles that in the opinion of the specialist physician will affect the quality of the cardiovascular imaging.