Effects of Medical Treatment of ICAS With Hemodynamic Disorders Based on MR-FFR

Launched by XUANWU HOSPITAL, BEIJING · Dec 25, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of medical treatments on patients with a condition called Intracranial Atherosclerosis (ICAS), which can lead to strokes. The goal is to see how different treatments work over the course of a year for patients whose blood flow is affected, as determined by a special MRI test. The main focus is to find out how many patients experience a stroke or die due to issues related to their condition within that year.

To participate, individuals must be between 30 and 80 years old and have specific symptoms related to ICAS in the front part of the brain. They should have significant narrowing of their arteries (between 50% to 99%) confirmed by imaging tests. Participants will be closely monitored throughout the study, and they must be able to understand and agree to the study’s procedures. However, those with certain medical conditions or who have had prior surgeries for brain issues, as well as pregnant women, are not eligible to join. Overall, this trial aims to improve how we treat patients with ICAS and potentially reduce the risk of serious complications like stroke.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients aged from 30 to 80 with symptomatic ICAS lesion in anterior circulation.
• • 2. 50% to 99% stenosis (in accordance with modified WASID method) confirmed by DSA, CTA or MRA.
• • 3. mRS 0-2 points
• • 4. Informed of the study protocol and objectives.
• Exclusion Criteria:
• • 1. Previous endovascular treatment or surgery for cerebrovascular diseases
• • 2. Large cerebral infarction (more than 1/2 MCA perfusion area) according to MRI
• • 3. Combined with other neurological diseases, such as aneurysm, arteriovenous malformation, tumor, hydrocephalus, cerebral trauma, cerebral hemorrhage, multiple sclerosis, epilepsy and intracranial infection.
• • 4. Pregnancy or in the preparation for pregnancy
• • 5. Patients who cannot tolerate or do not allow MR screening, including metal implanting and claustrophobia
• • 6. Contraindication for antiplatelet drugs or statins
• • 7. Patients with severe dementia or mental disorders, who cannot cooperate with examination