rTMS in Overactive Bladder

Launched by THE METHODIST HOSPITAL RESEARCH INSTITUTE · Jan 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called repetitive transcranial magnetic stimulation (rTMS) for patients with overactive bladder (OAB). OAB is a condition that causes a frequent and urgent need to urinate, which can significantly affect daily life and mental well-being. The trial aims to explore how rTMS, a non-invasive procedure that uses magnetic pulses to stimulate specific areas of the brain, can help improve symptoms of OAB and understand the changes in brain function associated with this treatment.

To participate in the trial, individuals must be between 40 and 80 years old and have experienced OAB symptoms for at least three months without a urinary tract infection. They should also have a certain level of cognitive function and meet specific criteria related to their urinary habits. Participants will receive rTMS treatment and will be monitored to see how it affects their symptoms and overall quality of life. Importantly, this study is one of the first to investigate how this brain stimulation technique could help those suffering from OAB, potentially offering new hope for improved treatment options.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Females \& Males
• • 40 to 80 years old
• • 3 months of OAB symptoms without active urinary tract infection currently
• * Bladder diary:
• • Mean voids/24 hours ≥ 8.0
• • Mean urgency episodes/24 hours ≥ 3.0
• • Montreal Cognitive Assessment (MoCA) score \>10
• Exclusion Criteria:
• • Pregnant, nursing, or self-report of planning to become pregnant.
• • Contraindication to MRI or to the Rapid2 Magstim Device as listed in the operator manual
• • Qmax \< 10 ml/s in males on uroflow
• • \< 20th percentile on Liverpool nomogram
• • Postvoid residual volume ≥ 200 mL, suprapubic or indwelling catheter
• • Personal or immediate family history of seizure disorder
• • Taking (bupropion) Wellbutrin or heavy alcohol use
• • Parkinson's disease, Multiple sclerosis, spinal cord injury
• • Intracranial lesions and hemorrhagic stroke within the last 12 months
• • History of interstitial cystitis, pelvic radiation, bladder augmentation
• • Intradetrusor botulinum toxin injections within 6 months
• • Pelvic floor therapy within 2 months.
• • Active/on-mode Sacral nerve stimulator (eligible if turned off)
• • Incarcerated patients