Determination of MCG Reference Intervals in Healthy Individuals

Launched by QILU HOSPITAL OF SHANDONG UNIVERSITY · Dec 27, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new method called magnetocardiography (MCG), which is a noninvasive way to check for heart problems. The goal of the study is to establish normal values for MCG readings in healthy adults in China. These reference values are important because they will help doctors better understand the test results and identify any potential heart issues in patients in the future.

To participate in this study, individuals must be at least 18 years old and have no history of heart disease or other serious health problems. They should not be taking any medications, have no recent hospital stays, and should not have high blood pressure, diabetes, or high cholesterol. Participants will undergo MCG testing, which is safe and painless, to help researchers gather the necessary data. This trial is currently looking for volunteers, and being part of it could contribute to important advancements in heart health assessments.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age 18 years or older.
• • 2. Those with no hospitalization for any reason in the 6 months prior to the study.
• • 3. Those who are not currently taking any prescribed medications.
• • 4. Those with no history of cardiovascular diseases, including coronary artery disease, structural heart disease, arrhythmia, heart failure, stroke, pulmonary embolism, aortic coarctation, or peripheral arterial disease.
• • 5. Those with no risk factors for cardiovascular diseases, including hypertension, diabetes mellitus, hyperlipidemia.
• • 6. Those with no history of smoking (previous non-smoking or smoking cessation \>6 months).
• • 7. Those with no excessive alcohol consumption (average daily alcohol consumption \<3 drinks, 1 drink = beer 355mL / white wine 44mL / red wine 118mL).
• • 8. Signed informed consent.
• Exclusion Criteria:
• • 1. Those with body mass index \>28kg/m2 or \<18kg/m2.
• • 2. Those with resting heart rate \<50 beats/min, or \>110 beats/min.
• • 3. Those with resting systolic blood pressure ≥ 140 mmHg, and/or diastolic blood pressure ≥ 90 mmHg.
• • 4. Those with fasting blood glucose ≥7 mmol/L, and/or random blood glucose ≥11.1 mmol/L.
• • 5. Those with total cholesterol ≥6.2 mmol/L or low-density lipoprotein cholesterol ≥4.1 mmol/L.
• • 6. Those with abnormal electrocardiograms, such as arrhythmias, ST-T changes, and pathologic electrical axis deflections.
• • 7. Those with cardiac ultrasonographic pathologic findings, such as left ventricular hypertrophy, left ventricular dilatation, abnormal ventricular wall motion, and valvular regurgitation or stenosis of more than mild degree.
• • 8. Those with respiratory diseases, kidney diseases, liver diseases, endocrine diseases, anaemia or other blood diseases, connective tissue diseases, malignant tumors and other diseases.
• • 9. Professional athletes, pregnant or lactating women, psychological or psychiatric disorders such as depression.
• • 10. Those who are unable to perform magnetocardiography due to claustrophobia, etc., or those who are unable to cooperate with the corresponding examinations required by the study for various reasons.