The Anesthesia Effects of Dexmedetomidine Combined With Desflurane or Propofol in Lobectomy

Launched by THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY · Jan 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different types of anesthesia—dexmedetomidine combined with desflurane versus dexmedetomidine combined with propofol—on patients undergoing a specific type of lung surgery called lobectomy. The goal is to find out if using dexmedetomidine with desflurane can help patients recover faster and reduce the chances of problems after surgery, like issues with breathing or nausea, without causing more confusion or delirium.

To participate in this trial, patients need to be adults (18 years or older) who are scheduled for elective thoracoscopic unilateral lobectomy surgery, which requires general anesthesia for at least one hour. However, certain individuals may not qualify, including those with obesity, severe heart or lung conditions, or other serious health issues. If eligible, participants can expect to receive one of the two anesthesia combinations during their surgery and will be monitored for their recovery and any complications afterward. This research aims to improve patient care and outcomes after lung surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients undergoing elective thoracoscopic unilateral lobectomy.
• • 2. General anesthesia is required and the expected duration of one-lung ventilation is ≥ 1h.
• • 3. American Association of Anesthesiologists (ASA) physical condition classification I-III.
• • 4. Patients over 18 years old.
• • 5. Voluntary participation and ability to understand and sign the informed consent.
• Exclusion Criteria:
• • 1. Obese patients (BMI\>28 kg/m2).
• • 2. patients with grade 3 hypertension (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg).
• • 3. Acute coronary syndrome, sinus bradycardia (heart rate \< 45 beats/min), II or III degree atrioventricular block, NYHA heart function classification III or IV.
• • 4. Patients with severe history of chronic obstructive pulmonary disease (GOLD grade III or IV of pulmonary function of chronic obstructive pulmonary disease), severe or uncontrolled bronchial asthma, pulmonary infection, bronchiectasis and thoracic deformity.
• • 5. Pulmonary artery pressure ≥60 mmHg.
• • 6. Patients with Child grade B or C of liver function.
• • 7. Patients with chronic kidney disease in stage 4 or 5.
• • 8. Patients with hyperthyroidism and pheochromocytoma.
• • 9. Patients who are expected to need mechanical ventilation after operation.
• • 10. People with hearing, intelligence, communication and cognitive impairment.
• • 11. For any reason, it is impossible to cooperate with the study or the researcher thinks that it is not suitable to be included in this experiment.
• • 12. patients who are expected to be transferred to ICU after operation.