I-PRF After Arthrocentesis Plus Botox Injection to Lateral Pterygoid Muscle in Treatment of Anterior Disc Displacement

Launched by FAYOUM UNIVERSITY · Jan 5, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new treatment approach for people suffering from painful jaw issues, specifically a condition known as TMJ (temporomandibular joint) disc disorder. The researchers want to see if combining a procedure called arthrocentesis (which helps remove fluid from the joint) with two types of injections—one using liquid platelet-rich fibrin (I-PRF) and another using botulinum toxin (commonly known as Botox) injected into a specific muscle in the jaw—can improve symptoms like pain, jaw movement, and clicking sounds when opening the mouth.

To be eligible for this trial, participants need to be between 16 and 45 years old, have pain when moving their jaw, experience clicking sounds, and have a reduced ability to open their mouth. They must also have a specific diagnosis confirmed by an MRI showing the disc in their jaw is displaced but can still be moved back into place. However, individuals with certain conditions, such as recent jaw trauma, allergies to Botox, or other systemic issues affecting the joints, will not be able to participate. Participants will receive the treatment and will be monitored to see how it affects their symptoms and jaw movement.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with painful tmj during jaw movements
• • Patients with joint sounds ( clicking ) during jaw opening and mastication
• • Patients age range from 16 years old to 45 years old
• • Patients with Class I maxillo-mandibular relationship
• • Patients with reduced mouth opening
• • All patients diagnosed clinically and radiographically by MRI as TMJ anterior disc displacement with reduction
• Exclusion Criteria:
• • Patient with history of recent trauma
• • Patients with malocclusion
• • Patients with systematic condition that affect bone and joints such as osteoarthritis , systemic lupus and epilepsy .
• • Patients allergic to botox injection
• • Pregnant or lactating females
• • Patients with non-reducible disc on MRI
• • Patients contraindicated to exposure to MRI
• • Patients with previous tmj arthrocentesis , arthroscopy or TMJ surgery
• • Significant mechanical obstruction that prevents mouth opening, acute capsulitis, benign or malignant temporomandibular joint lesions.
• • Patients with blood diseases, and coagulation disorders