Cortical Function Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome

Launched by THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY · Jan 5, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how the brain changes when patients with Lateral Medullary Syndrome (LMS) swallow food or liquids. People with LMS often have difficulty swallowing, known as dysphagia. Researchers want to see how the brain's activity and connections differ during swallowing in LMS patients compared to healthy individuals. They will use a special technology called functional near-infrared spectroscopy (fNIRS) to observe and compare brain activity in both groups.

To participate in this study, you need to be between 18 and 80 years old, right-handed, and have had your first stroke confirmed as LMS by an MRI. You should also have dysphagia confirmed by a swallow study and be able to cooperate during the testing. However, if you have other serious neurological or physical conditions, or if you are unable to cooperate, you won’t be eligible. If you join the study, you can expect to undergo tests that will help researchers better understand swallowing difficulties in LMS and potentially improve future treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The first ischemic stroke was confirmed by head MRI as LMS;
• • 18-80 years old, right-handed;
• • Dysphagia was confirmed by video fluoroscopic swallow study(VFSS);
• • Conscious enough to cooperate with fNIRS testing;
• • No previous neurological or mental illness.
• Exclusion Criteria:
• • Other central nervous system diseases (Parkinson's disease, Alzheimer's disease, intracranial tumors, etc.);
• • Other diseases causing dysphagia (tumors of the esophagus, larynx, nasopharynx, etc.);
• • Serious physical diseases (cancer, fracture, etc.);
• • Other mental disorders (mania, schizophrenia, etc.);
• • Unconscious, unable to cooperate with the examination