Perceptions of E-Cigarettes and Synthetic Cooling Agents, the ICE Study
Launched by OHIO STATE UNIVERSITY COMPREHENSIVE CANCER CENTER · Jan 16, 2024
Trial Information
Current as of August 19, 2025
Recruiting
Keywords
ClinConnect Summary
The ICE Study is looking at how certain cooling agents used in e-cigarettes, specifically WS-3 and WS-23, affect people's thoughts about e-cigarettes, how they use them, and their exposure to harmful substances. Researchers want to understand if these additives change the way e-cigarette users feel about vaping and whether they might impact health risks.
To participate in this study, you need to be between 21 and 29 years old and currently use e-cigarettes exclusively (meaning you haven't used any other tobacco or nicotine products in the last six months). You should also be willing to not use your e-cigarette for at least 12 hours before each of the four lab sessions, and you need to be comfortable reading and speaking English. If you qualify, you'll be asked to share your experiences in a controlled setting, and the study is currently recruiting participants. It's important to note that some medical conditions, like recent COVID-19 infections or serious lung diseases, may prevent you from being eligible.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Aged 21-29 years
- • Current exclusive e-cigarette (EC) user (defined as ≥ weekly use over the past 3 months)
- • Willing to provide informed consent and abstain from using their EC at least 12 hours prior to the four lab sessions
- • Read and speak English
- Exclusion Criteria:
- • Recently COVID-19+ (defined as positive test in the past 30 days) or a recent COVID-19 hospitalization (defined as a hospitalization within the past 6 months)
- • Unstable or significant psychiatric conditions (past and stable conditions will be allowed)
- • History of cardiac event or distress within the past 3 months
- • Are currently pregnant, planning to become pregnant, or breastfeeding (will be verified with urine pregnancy test)
- • Have suffered from any serious lung disease or infection (e.g. , tuberculosis, cystic fibrosis, or lung cancer) in the past 30 days
- • Have hemophilia or another type of bleeding disorder
- • Are blind, severely visually impaired, deaf, hard of hearing, or have a severe motor disability
About Ohio State University Comprehensive Cancer Center
The Ohio State University Comprehensive Cancer Center (OSUCCC) is a leading institution dedicated to advancing cancer research, treatment, and education. As a National Cancer Institute-designated comprehensive cancer center, OSUCCC integrates cutting-edge research with clinical practice to develop innovative therapies and improve patient outcomes. With a collaborative approach that unites scientists and clinicians, OSUCCC focuses on personalized medicine, cancer prevention, and community outreach, striving to enhance the understanding of cancer biology and provide hope to patients through groundbreaking clinical trials and comprehensive care programs.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Columbus, Ohio, United States
Patients applied
Trial Officials
Alayna P Tackett, PhD
Principal Investigator
Ohio State University Comprehensive Cancer Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported