Balloon Pulmonary Angioplasty vs. Combined Approach With Pulmonary Artery Denervation in CTEPH: Effectiveness Comparison
Launched by BORIS DZUDOVIC · Jan 15, 2024
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
This clinical trial focuses on advancing our understanding and treatment of chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH arises when blood clots in the lungs fail to fully dissolve, leading to the formation of fibrous masses that obstruct blood vessels, increase pulmonary blood pressure, and strain the heart's right ventricle.
The study's primary objective is to evaluate the combined use of two innovative treatments, Balloon Pulmonary Angioplasty (BPA) and Pulmonary Artery Denervation (PADN), in comparison to the standard treatment for CTEPH. BPA involves using a balloon to...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Written informed consent.
- • Age 18 - 80 years.
- • Diagnosis of chronic thromboembolic heart disease.
- • Mean pulmonary arterial pressure (mPAP) \>20 mmHg.
- • Pulmonary vascular resistance \>3 Wood units.
- • Presence of organized thrombus masses.
- • World Health Organization (WHO) functional class II to IV.
- Exclusion Criteria:
- • Proximal organized thrombotic masses not suitable for Balloon Pulmonary Angioplasty (BPA) and Pulmonary Artery Denervation (PADN).
- • WHO functional class I
- Additionally, participants can be excluded from the trial under the following circumstances:
- • Withdrawal of consent at any time.
- • Failure to complete the treatment as per protocols.
- • Protocol violations.
About Boris Dzudovic
Boris Dzudovic is a dedicated clinical trial sponsor committed to advancing medical research and improving patient outcomes through innovative clinical studies. With a strong emphasis on ethical practices and regulatory compliance, Boris Dzudovic collaborates with leading researchers and healthcare institutions to design and implement trials that address critical health challenges. His expertise in trial management and patient engagement ensures that studies are conducted efficiently while prioritizing participant safety and data integrity. Through a focus on collaboration and transparency, Boris Dzudovic aims to contribute significantly to the fields of medicine and healthcare.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Belgrade, , Serbia
Patients applied
Trial Officials
Slobodan Obradovic, MD, PhD
Principal Investigator
Clinic of Cardiology, Military Medical Academy, Belgrade, Serbia
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported