Propofol-Fentanyl-Dexmedetomidine and Propofol-Fentanyl-Sevoflurane Anesthesia for Major Spine Surgery Under Somato Sensory- and Motor- Evoked Potential Monitoring

Launched by AIN SHAMS UNIVERSITY · Jan 6, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring the effects of two different anesthesia methods on patients undergoing major spine surgery. Specifically, it is comparing a combination of medications called propofol, fentanyl, and dexmedetomidine with another combination that includes propofol, fentanyl, and sevoflurane. The goal is to see how adding dexmedetomidine affects certain signals in the nervous system that doctors monitor during surgery to ensure everything is functioning well.

To be eligible for this trial, participants need to be between 21 and 45 years old and in good health (classified as ASA physical status I or II). This means they should not have serious health issues that could complicate the surgery or anesthesia. Participants can expect to be closely monitored during their surgery, and their responses to the anesthesia will be carefully studied. It’s important to note that individuals with allergies to any of the study medications or certain medical conditions, like severe respiratory diseases or specific nerve disorders, will not be able to participate. If you think you might be a good candidate and are interested in learning more, please discuss it with your doctor.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age from 21-45 years.
• • Both sexes.
• • American Society of Anesthesiology (ASA) physical status I and II.
• • Undergoing major spine surgery
• Exclusion Criteria:
• • Refusal of procedure or participation in the study by patients.
• • Patients with known history of allergy to one of study drugs
• • Patients with nerve conduction pathway injury.
• • Severe circulatory or respiratory disease.
• • Cognitive or psychiatric illness that leads to inability to cooperate, speak or provide informed consent
• • Patients with history of Myasthenia gravis, epilepsy , history of pacemaker implantation .
• • Patients who need to be awakened during the procedure.