Hypertension and Arrhythmias in CLL Patients Treated with BTK Inhibitors

Launched by ABRAMSON CANCER CENTER AT PENN MEDICINE · Jan 9, 2024

Keywords

ClinConnect Summary

Given the significant morbidity and mortality associated with hypertension and AF including stroke, systemic thromboembolism and heart failure, monitoring asymptomatic patients who are at high risk is an important area of investigation in the general population and is clearly an area of substantial need in the setting of BTK inhibitor use. Leveraging technology (including wearable and digital devices) to evaluate for the development of arrhythmias is an area of increasing focus in the field of cardiology and has led to various partnerships with technology companies including Apple, Google a...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥22
• • Initiation of BTK inhibitor (acalabrutinib or zanubrutinib) with or without other concurrent systemic therapy as front line or relapsed/refractory therapy for chronic lymphocytic leukemia, ordered by treating oncologist per standard of care
• • Normal sinus rhythm at the time of consent
• • Ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information (in accordance with national and local patient privacy regulations).
• Exclusion Criteria:
• • Current use of a class IC or III antiarrhythmic medication
• • AF or other arrhythmia at the time of consent
• • Uncontrolled hypertension (≥140/90mmHg) at the time of consent
• • Inability to provide informed consent
• • Inability to wear a watch
• • Arm circumference too small (\< 9 in) or arm circumference too large (\> 14.5in.) to use the QardioArm cuff
• • Expected survival less than one year.
• • Pregnancy at time of consent
• • Lack of access to a personal Apple iPhone. If the patient does not have an Apple iPhone, but another member of the patient's household has an iPhone, the patient may still be enrolled as long as there is no other Apple Watch paired with the phone.