Smoldering Myeloma High-Risk Patient Observation and Longitudinal Insight Trial

Launched by UNIVERSITY OF UTAH · Jan 8, 2024

Keywords

ClinConnect Summary

The Smoldering Myeloma High-Risk Patient Observation and Longitudinal Insight Trial is studying a condition called smoldering multiple myeloma, which is an early stage of a type of blood cancer. The goal of this trial is to understand how this condition progresses over time in patients who are closely monitored using advanced imaging techniques. Researchers want to learn more about patients who are considered high-risk for developing more serious problems related to their smoldering myeloma.

To be eligible for the trial, participants must be at least 18 years old and have a diagnosis of high-risk smoldering myeloma, which is determined by specific test results showing certain protein levels or bone marrow characteristics. Participants can expect regular check-ups and imaging tests as part of their care throughout the study. It's important to know that this trial is currently recruiting participants, so if you or someone you know fits the eligibility criteria and is interested, they could consider joining to help advance our understanding of this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult subject aged ≥ 18 years.
• * Diagnosis of smoldering myeloma as per the IMWG criteria, specifically:
• • Serum monoclonal protein (IgG or IgA) of 30g/L or greater per 24 hours or urinary monoclonal protein of 500mg or greater per 24 hours and/or
• • Clonal bone marrow plasma cells 10-59% with the absence of myeloma-defining events or amyloidosis
• * High-risk smoldering myeloma defined as two or more out of four of the following criteria:
• • M-spike greater than 2 g/dL
• • An involved/uninvolved free light chain ratio greater than 20
• • Bone marrow plasmacytosis greater than 20%
• • Presence of any of translocation (4;14), deletion 17p, deletion 13q or 1q gain by conventional cytogenetics/fluorescence in situ hybridization (FISH) studies) and/or
• • An IMWG SMM score of 9 or greater according to the IMWG risk model for smoldering multiple myeloma (SMM)
• • Diagnosis of high-risk SMM made within 365 days of enrollment in the study. Note: If a patient previously had MGUS or low/intermediate SMM- the date at which high-risk SMM was diagnosed would have to be within 365 days of enrollment in the study.
• Exclusion Criteria:
• • Presence of any features that would meet diagnostic criteria for myeloma as per the IMWG Criteria
• • Presence of extramedullary plasmacytomas
• • Presence of any focal bone marrow lesions, or lytic bone lesions on imaging done prior to screening or on screening. However, presence of diffuse or patchy infiltration of the marrow (without any clear lesions) on MRI, will not be an exclusion criteria. Patients with 1 focal marrow lesion on MRI that is attributable to plasma cell dyscrasia, will be excluded from study, even if they do not meet criteria for myeloma.
• • Creatinine clearance of less than 40ml/min.
• • Presence of AL Amyloidosis (the amount of workup necessary to exclude AL Amyloidosis is per the discretion of the treating investigator, however the investigator must attest that they do not believe AL Amyloidosis to be present at time of enrollment. Serum nt-PROBNP is recommended as part of evaluation in order to ascertain for cardiac amyloidosis).
• • Hemoglobin of less than 11g/dl, unless a clearly reversible reason for anemia is identified, at which point they can be rescreened in two months if Hgb is greater than 11g/dl.
• • Note: The Hgb cut-offs can vary between institutions (lower cut-off for Hgb University of Utah for men is a Hgb of 14.8, rendering a patient with Hgb of 12.7 as having a CRAB feature). If the Hgb is above 10g/dl but the patient meets the definition of anemia according to the IMWG criteria, by virtue of this being more than 2 g/dl below the limit of normal, the investigator can decide whether to call a patient being considered for screening as having multiple myeloma OR smoldering myeloma and allow enrollment on this study.