Gastrointestinal Decompression in Stroke

Launched by TIANJIN MEDICAL UNIVERSITY GENERAL HOSPITAL · Jan 10, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a treatment called gastrointestinal decompression for patients who have suffered from a severe type of stroke known as acute ischemic stroke. This type of stroke can lead to serious complications like stomach bleeding and infections, which can worsen a patient's condition. The goal of the study is to see if early gastrointestinal decompression can safely reduce stomach acid and prevent these complications, potentially improving outcomes for patients.

To participate in this trial, individuals must be between the ages of 18 and 80 and have experienced a severe stroke with specific symptoms. They should also be within 24 hours of the stroke event and have a good level of function before the stroke. During the trial, participants will receive the gastrointestinal decompression treatment, and the researchers will monitor their health to evaluate how well the treatment works and if it is safe. It's important to note that people with certain health issues, like recent infections or those planning to undergo other specific treatments, may not be eligible to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18-80 years
• • severe AIS, including NIHSS score\>20 in dominant hemisphere infarction, or NIHSS score\>15 in non-dominant hemisphere infarction, or NIHSS consciousness score \>1; · massive infarction, characterized by infarction area larger than 1/3 of the effected middle cerebral artery territory and/or the cerebellum territory presented in admitted computed tomography (CT) or MRI
• • onset-to-needle time within 24 hours
• • prestroke modified Ranking scales (mRS)≤1
• • sign the informed consent.
• Exclusion Criteria:
• • Recent respiratory infection and/or gastrointestinal bleeding
• • austere diseases such as tumors and dyscrasia
• • intention to undergo emergency thrombectomy
• • pregnant women or nursing mother
• • contraindication for gastric tubes
• • participating in other clinical trials within previous 3 months.