Effect of PP in Patients With Ultra-low VT

Launched by SOUTHEAST UNIVERSITY, CHINA · Jan 10, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of placing patients in a "prone position" (lying on their stomachs) while they receive a special type of breathing support called venovenous extracorporeal membrane oxygenation (VV-ECMO) with very low tidal volume ventilation. The goal is to see if this position helps improve lung function and blood flow in patients suffering from acute respiratory distress syndrome (ARDS), a serious condition where the lungs can't provide enough oxygen to the body. The trial is looking for adult patients who are on mechanical ventilation and have been on VV-ECMO for less than 48 hours.

To participate, patients must be 18 years or older and not have any serious heart or lung problems that would prevent them from lying in a prone position. Participants can expect close monitoring and care during the trial, as researchers will evaluate how their lungs respond to this treatment. It's important to note that the trial is currently recruiting participants, and those interested should discuss their eligibility with their doctor to ensure they meet the criteria.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients were enrolled if they were undergoing invasive mechanical ventilation and were supported by VV-ECMO for less than 48 hours
• Exclusion Criteria:
• • younger than 18 years old
• • contraindications for prone position ventilation
• • past chronic respiratory diseases (long-term family oxygen therapy for chronic
• • respiratory diseases such as pulmonary fibrosis or COPD)
• • New York Heart Association class above II
• • contraindications to the use of EIT (e.g., presence of pacemaker or chest surgical wounds dressing) or prone position (as decided by the attending physician)
• • severe hemodynamic instability
• • gave written or witnessed verbal informed consent