Multi-omics Analysis to Characterize the Invasive Evolution of Pulmonary Subsolid Nodules

Launched by CANCER INSTITUTE AND HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCES · Jan 18, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a specific type of lung nodules called pulmonary subsolid nodules (SSNs), which can sometimes lead to lung cancer, particularly adenocarcinoma. Researchers want to better understand how these nodules grow and become more invasive over time. Currently, doctors mainly monitor these nodules by checking if they grow, but this method may not provide a complete picture of their danger. By using advanced techniques to analyze biological information and imaging scans, the study aims to improve how doctors evaluate the growth and risk of SSNs. This could lead to more accurate treatment decisions and better use of healthcare resources, ultimately helping patients live longer.

To participate in this trial, patients must have newly diagnosed SSNs that have been confirmed by a special CT scan and be willing to undergo surgery. They should also be able to agree to the study voluntarily. Healthy volunteers aged 18 to 50 can also join, as long as they have no lung nodules or history of cancer. Participants can expect to undergo some imaging tests and possibly surgery, contributing to important research that may help future patients with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with SSNs
• • 1. Newly diagnosed patients with persistent SSNs confirmed by thin-section chest CT examination
• • 2. Patient areilling to undergo surgery
• • 3. Voluntarily sign a written informed consent form
• • Healthy Volunteers
• • 1. Healthy volunteers aged 18-50 years, regardless of gender.
• • 2. No lung nodules detected on chest thin-section CT.
• • 3. No history of cancer.
• • 4. Voluntary sign a written informed consent form.
• Exclusion Criteria:
• • Patients with SSNs
• • 1. Surgical contraindications
• • 2. Inability to cooperate with CT/MR examination to obtain high-quality images
• • 3. History of malignant tumors
• • 4. Previous targeted, immune, or ablation therapy
• • 5. Postoperative pathology of non-lung adenocarcinoma disease spectrum
• • 6. Other situations deemed unsuitable for participation in this study by the researchers
• • Healthy Volunteers
• • 1. Drug abuse
• • 2. HIV infection or AIDS
• • 3. History of syphilis, gonorrhea, or other infectious diseases
• • 4. Hepatitis B or C virus carrier