BCAAs, Muscle Protein Synthesis and Glucose Uptake

Launched by WAGENINGEN UNIVERSITY · Jan 11, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different types of amino acids in a drink affect how well our bodies use insulin and build muscle. Specifically, the researchers want to see the differences between a drink that contains all amino acids and one that is missing branched-chain amino acids (BCAAs), which are important for muscle health. The goal is to understand how these drinks can influence muscle growth and the body’s ability to take in glucose, which is a type of sugar that provides energy.

To participate in this study, you should be between 18 and 35 years old, have a healthy weight (not too underweight or overweight), and engage in regular physical activity at least once a week. However, certain conditions will exclude you, such as smoking, diabetes, heart disease, or any serious health issues. If you join the trial, you will consume one of the test drinks and help researchers gather important information about muscle and insulin response. The study is currently looking for participants, so if you fit the eligibility criteria and are interested, this could be a great opportunity!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged from 18-35 years
• • 18.5 \< Body mass index \< 30 kg·m2
• • Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)
• Exclusion Criteria:
• • Smoking
• • Diabetes (Type 1, Type 2, or genetic form of diabetes)
• • Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
• • Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
• • Known allergy to lidocaine
• • Regular use of dietary protein and/or amino acid supplements (\>3 times per week)
• • Currently involved in a structured progressive resistance training programme (\>3 times per week)
• • A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia.
• • Any previous motor disorders or disorders in muscle and/or lipid metabolism
• • Presence of an ulcer in the stomach or gut and/or strong history of indigestion
• • Known severe kidney problems
• • Pregnant or breastfeeding
• • Unable to give consent