Corneal and Tear Film Changes in Chinese Patients With Type 2 Diabetes

Launched by HE EYE HOSPITAL · Jan 22, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how diabetes affects the eyes, specifically looking at changes in the cornea (the clear front part of the eye) and tear film in Chinese patients with Type 2 Diabetes. The researchers want to understand how diabetes may cause problems like dry eye disease, which can make your eyes feel uncomfortable or irritated. To do this, they will compare 200 patients with Type 2 Diabetes who have dry eyes to 200 people of the same age and gender who do not have diabetes.

To participate in this study, you need to be at least 18 years old and diagnosed with dry eye disease based on specific criteria, like answering certain questions about your eye comfort and having particular test results. However, if you have an active eye infection, have had recent eye surgery, or wear contact lenses regularly, you may not be eligible to join. Participants can expect to undergo eye examinations and tests to assess their eye health. This study is currently recruiting participants, and your involvement could help improve understanding of how diabetes impacts eye health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants are diagnosed with dry eye according to the TFOS DEWS II diagnostic criteria: (a) OSDI questionnaire ≥13, (b) Non-invasive tear breakup time (NITBUT) \<10 s, (c) ocular surface staining \>5 corneal spots, greater than nine conjunctival spots (The presence of two or more criteria was used to establish a positive DE diagnosis).
• • Age ≥ 18
• Exclusion Criteria:
• • Active ocular infection, such as infectious, viral, chlamydial, or immunologic conjunctivitis
• • A history of ocular surgery that might affect the corneal or tear film, such as corneal refractive surgery, keratoplasty, cataract surgery, or ocular laser surgery
• • Long-term contact lens wear
• • Other ocular diseases being treated might affect the corneal or tear film: such as glaucoma, dacryocystitis, uveitis, and pterygium.