Investigating the Effect of Chlorine Dioxide and Chlorhexidine Mouthwash on Bad Breath

Launched by SEMMELWEIS UNIVERSITY · Jan 12, 2024

Keywords

ClinConnect Summary

The ODOR trial is a clinical study designed to investigate how effective two different mouthwashes are at reducing bad breath, also known as halitosis. Specifically, the trial will compare hyperpure chlorine dioxide mouthwash to chlorhexidine mouthwash over a short period of three hours. The main goal is to see how much each mouthwash improves breath freshness, measured through a special test that assesses breath odor.

To participate in this trial, individuals should be aged between 65 and 74 years and have at least 20 teeth. They will need to meet certain conditions, such as having a specific level of bad breath and following strict guidelines about eating, drinking, and using scented products before the study. Participants will not be allowed to take antibiotics or have certain medical conditions that could affect the results. This study is not yet recruiting participants, but those who qualify can expect to use one of the mouthwashes and have their breath odor tested to help researchers understand which product works better.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Organoleptic test score (OLS)\>=2 for IOH
• • Patients with at least 20 teeth
• • 8 hours of scented oral hygiene product usage, 4 hours of eating, and 2 hours of drinking restriction
• • on the day of investigation, restriction of alcohol, caffeine, perfume usage, and food intake with characteristic smell
• Exclusion Criteria:
• • Medical history of systematic and infectious diseases (e.g., hepatitis, HIV, tuberculosis).
• • Antibiotic use within the month before the study's start or during the trial or any regular medication
• • Extraoral halitosis (will be distinguished by observing the nasal breath)
• • Eat foods (like garlic) linked to oral malodor on the day before and the sampling day, as well as wear heavily fragrant cosmetics on that day.
• • Patients with removable dentures
• • Smokers (Cigars, Cigarettes, Pipes, Chewing tobacco, e-cigarette, or vaping products used in the last month)