CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

Launched by MAYO CLINIC · Jan 12, 2024

Keywords

ClinConnect Summary

The CAMERA Study is a clinical trial designed to understand how the heart and lungs work together in healthy adults during rest and exercise. Researchers want to measure certain pressures and blood flow in the body, which can help them learn more about heart health. This study is recruiting healthy volunteers aged 65 to 74 who do not have symptoms of breathlessness or fatigue and have a good heart function (specifically, a left ventricular ejection fraction of 50% or higher).

To participate, individuals must not have any history of heart failure or significant heart or lung problems. If you join the study, you'll undergo some tests that may include exercise testing and MRI scans to gather important information about your cardiovascular health. It’s a great opportunity to contribute to research that could benefit future heart health understanding, and all participants will need to give their consent before taking part.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Apparently healthy volunteers are eligible to participate in this study if they are free of symptoms of exertional breathlessness or fatigue and any diagnosis of heart failure.
• • Patients will also be required to have left ventricular ejection fraction (EF) ≥ 50%.
• • Patients discovered to reduced EF or abnormal resting hemodynamics or other pathologic findings previously undiscovered will be considered screen failures and can be replaced by others to reach the goal enrollment.
• • Informed consent were obtained.
• • No history of heart failure.
• • Willing and able to undergo invasive hemodynamic exercise testing, MRI, and other study assessments.
• Exclusion Criteria:
• • Clinically significant symptoms of exertional dyspnea or fatigue in daily life in the opinion of the investigators.
• • Any diagnosis of heart failure
• • Symptomatic coronary artery disease (e.g., patients with chronic angina)
• • Symptomatic valvular heart disease
• • Pulmonary hypertension
• • Cardiomyopathies
• • High output heart failure
• • Pericardial disease
• • Clinically significant chronic lung disease in the opinion of the investigators
• • Anemia (hemoglobin \<12 gm/dL in women and \<13 gm/dL in men)
• • Estimated glomerular filtration rate ≤30mL/min
• • Pregnant women
• • Any other disorders or problems that would interfere with the ability to participate safely in the study (e.g. psychiatric disorder or substance abuse)