Search / Trial NCT06221644

Synapse Alterations in MSA Patients

Launched by XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY · Jan 15, 2024

Trial Information

Current as of December 22, 2024

Completed

Keywords

Synaptic Density; Pet; Sv2 A

ClinConnect Summary

60 MSA patients (30 MSA-P subtype and 30 MSA-C subtype) and 30 age-matched healthy controls (HCs) underwent \[18F\]SynVesT-1 PET/CT for synaptic density assessment. Visual, voxel, and volumetric region-of-interest (VOI) analyses were employed to elucidate synaptic density patterns in the MSA brain and establish visual diagnostic criteria. VOI-based computer-assisted analyses were utilized to develop diagnostic models for MSA.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • The MSA patient were diagnosed according to the 2008 Second Consensus Criteria and confirmed by two experienced neurologists.
  • Exclusion Criteria:
  • encompassed MRI contraindications, a history of epilepsy, stroke, or brain surgery, intracranial organic lesions unrelated to MSA, usage of levetiracetam or brivaracetam, and a history of alcohol or drug abuse

Trial Officials

Shuo Hu

Study Chair

Shuo Hu

About Xiangya Hospital Of Central South University

Xiangya Hospital of Central South University is a leading academic medical institution located in Changsha, China, renowned for its commitment to advancing healthcare through innovative clinical research and patient-centered care. As a key affiliate of Central South University, the hospital integrates clinical practice with medical education and research, fostering an environment that promotes the development of cutting-edge therapies and treatments. With a diverse array of specialized departments and a dedicated team of healthcare professionals, Xiangya Hospital actively participates in clinical trials aimed at enhancing medical knowledge and improving patient outcomes, contributing significantly to the global medical community.

Locations

Changsha, Hunan, China

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0