TIPS for PH Patients: an Observational, Cohort Study

Launched by NANFANG HOSPITAL, SOUTHERN MEDICAL UNIVERSITY · Jan 15, 2024

Keywords

ClinConnect Summary

The "TIPS for PH Patients" study is looking at how a treatment called TIPS (Transjugular Intrahepatic Portosystemic Shunt) can help patients with portal hypertension caused by cirrhosis, which is a serious liver condition. The researchers want to understand how this procedure affects patients over time, particularly in terms of infections, liver function, and other health issues. To do this, they will collect various samples from participants before the procedure and monitor their health for up to two years after TIPS is done.

To be eligible for this study, participants must be between 18 and 85 years old and undergoing TIPS due to complications related to portal hypertension. They need to provide signed consent to participate. However, those with certain conditions, like liver cancer or severe heart and lung diseases, cannot take part. Participants can expect regular follow-ups and testing to gather information that will help improve future treatments for similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients undergoing TIPS due to complications related to portal hypertension；
• • 2. Age between 18 to 85 years;
• • 3. Signed informed consent;
• Exclusion Criteria:
• • 1. Combined with liver cancer (out of the Milan criteria) or combined with other organ malignancies which had less than 3 months of expected survival;
• • 2. Combined with severe cardiopulmonary disease (severe pulmonary hypertension and heart failure or severe heart valve insufficiency or renal insufficiency), the expected survival is less than 3 months;
• • 3. Failure of TIPS procedure;
• • 4. Women who plan to become pregnant or who are pregnant or breastfeeding；
• • 5. Conditions deemed unsuitable for study participation by the investigator.