Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors
Launched by FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS · Jan 15, 2024
Trial Information
Current as of August 20, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is focused on understanding how lactate levels change after major abdominal surgery and whether certain genetic factors might influence these changes. Lactate is a substance in the body that can increase due to stress, but not all increases are concerning. The researchers want to find out if higher lactate levels right after surgery are connected to specific genetic variations in patients. They will also look at whether these genetic factors might affect how long patients stay in the recovery room or hospital and if they experience any complications after surgery.
To take part in this study, participants must be at least 18 years old and scheduled for elective major abdominal surgery. Before surgery, they will undergo a genetic test to check for these specific variations. This trial is currently not recruiting participants, but it aims to help improve patient care by identifying which patients might be at risk for issues related to lactate levels after surgery.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age ≥ 18 years
- • Indication for elective major abdominal surgery
- Exclusion Criteria:
- • Age \<18 years
- • Liver cirrhosis
- • Liver surgery
- • Intraoperative chemotherapy
- • Previous gastric bypass surgery (thiamine deficiency)
- • Severe cardiovascular/respiratory impairment
- • Mitochondrial diseases
- • Pheochromocytoma
- • Chronic renal failure ≥ stage III
- • Refusal to sign the informed consent
About Fondazione Policlinico Universitario Agostino Gemelli Irccs
Fondazione Policlinico Universitario Agostino Gemelli IRCCS is a leading research and healthcare institution based in Rome, Italy, renowned for its commitment to advancing medical science and improving patient care. As a prominent academic medical center affiliated with the Catholic University of the Sacred Heart, it integrates clinical practice, education, and research, fostering innovation in various fields of medicine. The foundation conducts a wide range of clinical trials aimed at developing new therapies and enhancing treatment protocols, with a focus on translational research that bridges the gap between laboratory discoveries and patient care. Its multidisciplinary approach and dedication to high ethical standards position it as a key player in the landscape of clinical research and healthcare improvement in Italy and beyond.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Rome, , Italy
Rome, Italy/Lazio, Italy
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported