Study to Evaluate the Safety and Efficacy of Bicalutamide in Combination with Sunitinib in Patients with TKIs-resistant RCC

Launched by STATE UNIVERSITY OF NEW YORK AT BUFFALO · Jan 18, 2024

Keywords

ClinConnect Summary

This clinical trial is testing a combination of two medications, bicalutamide and sunitinib, to see if they are safe and effective for patients with advanced renal cell carcinoma (RCC), which is a type of kidney cancer. This trial is specifically for people whose cancer has continued to progress despite previous treatments with a certain type of drug called a receptor tyrosine kinase inhibitor (RTKI). The study is currently looking for participants aged 18 and older, who have measurable disease and can provide consent to join the trial.

Participants can expect to receive treatment with both medications and will be closely monitored for any side effects or improvements in their condition. To join, they need to meet certain criteria, such as having good overall health and organ function, and women who can become pregnant must have a negative pregnancy test and agree to use contraception. It's important for potential participants to know that they should not be pregnant or breastfeeding and should have a life expectancy of at least six months. This trial aims to gather important information that could help in treating advanced kidney cancer in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Be willing and able to provide written informed consent for the trial.
• • 2. Be greater than or equal to 18 years of age on day of signing informed consent.
• • 3. Have measurable disease based on RECIST 1.1
• • 4. Have a performance status of 0-2 on the Eastern Cooperative Oncology Group (ECOG) Performance Scale
• • 5. Demonstrate adequate organ function
• • 6. Female subject of childbearing potential should have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of study medication.
• • 7. Subjects of childbearing potential should be willing to use 2 methods of contraception for the course of the study through 120 days after the last dose of study medication
• • 8. Male subjects without a previous vasectomy should agree to use an adequate method of contraception (i.e. abstinence, condom with spermicidal foam/gel/film/cream) starting with the first dose of study therapy through 120 days after the last dose of study therapy.
• • 9. Subjects have archival tumor tissue available or are willing to undergo a baseline biopsy prior to treatment.
• • 10. Subjects must have a life expectancy of at least 6 months.
• Exclusion Criteria:
• • 1. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment.
• • 2. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment.
• • 3. Has active Bacillus tuberculosis (TB)
• • 4. Has a known additional malignancy that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the skin that has undergone potentially curative therapy or in situ cervical cancer.
• • 5. Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
• • 6. Has an active infection requiring systemic therapy.
• • 7. Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator.
• • 8. Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
• • 9. Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the pre-screening or screening visit through 120 days after the last dose of trial treatment.
• • 10. Has a known history of Human Immunodeficiency Virus (HIV)
• • 11. Has known active Hepatitis B or Hepatitis C
• • 12. Has received a live vaccine within 30 days of planned start of study therapy