Search / Trial NCT06223035

Myokine Identification Following Acute Exercise

Launched by ROCKEFELLER UNIVERSITY · Jan 15, 2024

Trial Information

Current as of October 04, 2024

Recruiting

Keywords

Description

Acute exercise stimulates a cascade of responses within the human body. Not only do tissues work in an autonomous manner, but they also secrete factors mediating interorgan communication. Recent human research identified \>600 proteins secreted into the circulation following an acute bout of exercise, many of which are predicted to derive from the skeletal muscle and target the adipose tissue. Indeed, human studies have validated the effect exercise-induced myokines have upon adipose physiology, most notably IL-6. While insightful, identification of myokines and their tissue of target (i.e....

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * passing the PARQ questionnaire (i.e. answering "NO" to all questions)
  • * being between the ages of 18-45
  • * being moderately active (defined as participating in 30 minutes of recreational activity at least once per week for the past 3 months but no more than 3 times per week)
  • * non-smoking
  • * free of metabolic or cardiovascular diseases
  • Exclusion Criteria:
  • * unhealed fractures
  • * thrombophlebitis (blood clots)
  • * recent surgery of the upper or lower extremities (any surgeries in past 6 months at the ankle or foot, or in the past year at the knee, hip, shoulder or elbow)
  • * recent uncontrolled bruising
  • * recent muscle, bone or joint damage which interferes with regular physical activity
  • * taking part in vigorous physical activity more than 3 times per week
  • * any prior sensations of chest pain during exercise.
  • * individuals who are pregnant as determined by an on-site pregnancy test
  • * individuals who are currently taking exogenous hormones
  • * individuals who chronically consume NSAIDS or other anti-inflammatory medication (every day for the previous 3 months)
  • * failing the PARQ questionnaire as indicated by answering "YES" to any of the questions
  • * Having a BMI \>32
  • * Any medical condition that in the opinion of the investigator will confound interpretation of data for analysis.

About Sponsor

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

New York, New York, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0