DBS Imaging-based vs. Threshold Assessment-based Programming

Launched by ACADEMISCH MEDISCH CENTRUM - UNIVERSITEIT VAN AMSTERDAM (AMC-UVA) · Jan 23, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at two different ways to program a treatment called deep brain stimulation (DBS) for people with Parkinson's disease. The main goal is to see if using brain imaging to guide the DBS programming can help reduce motor symptoms just as effectively as a method that measures patients' responses to specific movements. Participants in the study will either receive the imaging-based programming or the threshold assessment-based programming, and their progress will be monitored over six months.

To join the trial, participants must be at least 18 years old and have a diagnosis of Parkinson's disease. They should also be scheduled for DBS screening and understand the Dutch language. However, people with certain conditions, like dementia or severe mental health issues, or those who have had previous brain surgeries, won't be eligible. Throughout the study, participants can expect careful monitoring of their motor symptoms, physical abilities, and overall quality of life to see how effective each programming method is.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Parkinson's disease diagnosis based on the clinical diagnostic criteria of Movement Disorder Society
• • Scheduled for DBS screening
• • Age of 18 years or older
• • Understand the Dutch language
• Exclusion Criteria:
• • Legally incompetent adults
• • No written informed consent
• • Previous functional stereotactic neurosurgery
• • Dementia
• • Current depression or psychosis