Nctid:
NCT06223555
Payload:
{"hasResults"=>false, "derivedSection"=>{"miscInfoModule"=>{"versionHolder"=>"2024-10-04"}, "conditionBrowseModule"=>{"meshes"=>[{"id"=>"D000009765", "term"=>"Obesity"}], "ancestors"=>[{"id"=>"D000050177", "term"=>"Overweight"}, {"id"=>"D000044343", "term"=>"Overnutrition"}, {"id"=>"D000009748", "term"=>"Nutrition Disorders"}, {"id"=>"D000001835", "term"=>"Body Weight"}], "browseLeaves"=>[{"id"=>"M12701", "name"=>"Obesity", "asFound"=>"Obesity", "relevance"=>"HIGH"}, {"id"=>"M26186", "name"=>"Overweight", "relevance"=>"LOW"}, {"id"=>"M25307", "name"=>"Overnutrition", "relevance"=>"LOW"}, {"id"=>"M12684", "name"=>"Nutrition Disorders", "relevance"=>"LOW"}, {"id"=>"M5114", "name"=>"Body Weight", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"Nutritional and Metabolic Diseases", "abbrev"=>"BC18"}, {"name"=>"Symptoms and General Pathology", "abbrev"=>"BC23"}, {"name"=>"All Conditions", "abbrev"=>"All"}]}}, "protocolSection"=>{"designModule"=>{"phases"=>["NA"], "studyType"=>"INTERVENTIONAL", "designInfo"=>{"allocation"=>"RANDOMIZED", "maskingInfo"=>{"masking"=>"SINGLE", "whoMasked"=>["PARTICIPANT"]}, "primaryPurpose"=>"BASIC_SCIENCE", "interventionModel"=>"CROSSOVER"}, "enrollmentInfo"=>{"type"=>"ESTIMATED", "count"=>96}}, "statusModule"=>{"overallStatus"=>"RECRUITING", "startDateStruct"=>{"date"=>"2024-08-23", "type"=>"ACTUAL"}, "expandedAccessInfo"=>{"hasExpandedAccess"=>false}, "statusVerifiedDate"=>"2024-09-25", "completionDateStruct"=>{"date"=>"2026-12-31", "type"=>"ESTIMATED"}, "lastUpdateSubmitDate"=>"2024-09-26", "studyFirstSubmitDate"=>"2024-01-24", "studyFirstSubmitQcDate"=>"2024-01-24", "lastUpdatePostDateStruct"=>{"date"=>"2024-09-27", "type"=>"ACTUAL"}, "studyFirstPostDateStruct"=>{"date"=>"2024-01-25", "type"=>"ACTUAL"}, "primaryCompletionDateStruct"=>{"date"=>"2026-06-30", "type"=>"ESTIMATED"}}, "outcomesModule"=>{"primaryOutcomes"=>[{"measure"=>"To determine whether an adjusted energy dose MMTTor a fixed dosed meal will result in greater variability in glucose area under the curve (AUC) within the same participants across a range of BMIs.", "timeFrame"=>"Baseline, Visit 3/4", "description"=>"Glucose AUC associated with MMTT conditions (fixed vs. adjusted)."}], "secondaryOutcomes"=>[{"measure"=>"Body Composition", "timeFrame"=>"Baseline, Visit 3/4", "description"=>"Change in energy expenditure associated with MMTT conditions (fixed vs. adjusted)."}, {"measure"=>"Resting Metabolic Rate", "timeFrame"=>"Baseline, Visit 3/4", "description"=>"Change in energy expenditure associated with MMTT conditions (fixed vs. adjusted)."}, {"measure"=>"Lipids", "timeFrame"=>"Baseline, Visit 3/4", "description"=>"Change in energy expenditure associated with MMTT conditions (fixed vs. adjusted)."}]}, "oversightModule"=>{"isFdaRegulatedDrug"=>false, "isFdaRegulatedDevice"=>false}, "conditionsModule"=>{"keywords"=>["Healthy Volunteer", "Obesity", "Body Composition", "Diet", "Mixed Meal Test", "Glucose"], "conditions"=>["Obesity", "Healthy Volunteer"]}, "referencesModule"=>{"seeAlsoLinks"=>[{"url"=>"https://clinicalstudies.info.nih.gov/cgi/detail.cgi?A_001707-DK.html", "label"=>"NIH Clinical Center Detailed Web Page"}]}, "descriptionModule"=>{"briefSummary"=>"Background:\n\nResearchers use mixed meal tolerance tests (MMTTs) to look at how people s bodies respond to eating a meal. However, researchers do not agree on how to decide the number of calories to give in each meal. Some use fixed meals, which are the same size for everyone, and some use adjusted meals, based on the size of the person s body. Researchers want to know which MMTT is best to use for future research.\n\nObjective:\n\nTo learn how fixed vs adjusted meals affect blood glucose levels in healthy people.\n\nEligibility:\n\nHealthy people aged 18 years or older.\n\nDesign:\n\nParticipants will have 3 or 4 clinic visits of up to 8 hours in 8 weeks.\n\nParticipants will have baseline tests:\n\nTheir height, weight, and waist size will be measured.\n\nThey will have an oral glucose tolerance test: A needle attached to a tube (IV) will be inserted into a vein in the arm. They will have a sugary drink. Blood samples will be taken from the tube at intervals up to 3 hours after the drink.\n\nThey will have a body scan.\n\nParticipants will have 2 MMTT visits. One will include a fixed meal and one will include an adjusted meal. They will have tests at both visits:\n\nResting metabolic rate: A clear hood will be placed over the participant s head while they rest for 20 minutes. This will measure the oxygen they breathe in and out.\n\nMMTT. Participants will have 5 minutes to drink a liquid meal. Blood samples will be taken at intervals for the next 4 hours....", "detailedDescription"=>"Study Description:\n\nThis study will be an outpatient study completed in 3-4 separate visits. We will compare two methods of dosing (fixed and adjusted) a mixed meal tolerance test (MMTT) to determine which results in greater physiological variability in hormone response. Ultimately, the goal is to determine which method of dosing is more appropriate in a research setting.\n\nObjectives:\n\nPrimary Objective:\n\nTo determine whether an adjusted energy dose MMTT or a fixed dosed meal will result in greater variability in glucose area under the curve (AUC) within the same participants across a range of BMIs.\n\nSecondary Objectives:\n\nTo determine whether baseline body composition, blood parameters (lipids, hormones, etc), and resting metabolic rate are associated with MMTT responses and whether this association is moderated by MMTT condition (fixed vs. adjusted).\n\nEndpoints:\n\nPrimary Endpoint: Glucose area under the curve (AUC)\n\nSecondary Endpoints: Area under the curve (AUC), incremental area under the curve (iAUC), value and timing of the absolute maximum (peak), value and timing of the inflection point after the absolute maximum value, value and timing of the maximum rate of incline, value and timing of the maximum rate of decline, total number of critical points with body composition, blood parameters, and resting metabolic rate as predictors."}, "eligibilityModule"=>{"sex"=>"ALL", "stdAges"=>["ADULT", "OLDER_ADULT"], "maximumAge"=>"99 years", "minimumAge"=>"18 years", "healthyVolunteers"=>true, "eligibilityCriteria"=>"* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Provision of signed and dated informed consent form.\n* Agreement to adhere to Lifestyle Considerations throughout study duration.\n* Males and females; Age \\>= 18years\n* Healthy, as determined by medical history, physical examination, and laboratory tests.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this\n\nstudy:\n\n* Current use of medications, dietary supplements, or alternative therapies known to alter energy metabolism.\n* Fasting plasma glucose \\>= 126 mg/dL\n* Type I or Type II Diabetes Mellitus by self-report.\n* Hematologic disorders including significant anemia (male hemoglobin \\< 13.0 g/dL or female hemoglobin \\< 11.0 g/dL)\n* Current pregnancy, pregnancy within the past 6 months or currently lactating\n* History or self-report of gastrointestinal disease, including inflammatory bowel diseases (e.g. Chron s disease and ulcerative colitis), malabsorption syndromes (e.g. celiac disease), gastric ulcer (active) which may alter metabolism or absorption of study food by self-report\n* Evidence of alcohol abuse as defined by an 8-point score on the Alcohol consumption screening AUDIT questionnaire in adults.\n* Participants who report taking large doses of acetaminophen (\\> 3 grams daily) who cannot stop acetaminophen 24 hours prior to and following the meal tests will be excluded from the study.\n* Inability to consume provided food based on a food allergy or intolerance.\n* Conditions not specifically mentioned above may serve as criteria for exclusion at the discretion of the investigators.\n* Any disorder, unwillingness, or inability not covered by any other exclusion criteria which, in the investigator s and/or team s opinion, jeopardizes the safety of the participant or others or would interfere with adherence to the protocol (such as claustrophobia).\n\nConditions not specifically mentioned above may serve as criteria for exclusion at the discretion of the investigators."}, "identificationModule"=>{"nctId"=>"NCT06223555", "briefTitle"=>"Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose", "organization"=>{"class"=>"NIH", "fullName"=>"National Institutes of Health Clinical Center (CC)"}, "officialTitle"=>"Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose", "orgStudyIdInfo"=>{"id"=>"10001707"}, "secondaryIdInfos"=>[{"id"=>"001707-DK"}]}, "armsInterventionsModule"=>{"armGroups"=>[{"type"=>"ACTIVE_COMPARATOR", "label"=>"1", "description"=>"Fixed Mixed Meal Test", "interventionNames"=>["Other: Fixed Mixed Meal Test"]}, {"type"=>"ACTIVE_COMPARATOR", "label"=>"2", "description"=>"Adjusted Mixed Meal Test", "interventionNames"=>["Other: Adjusted Mixed Meal Test"]}], "interventions"=>[{"name"=>"Fixed Mixed Meal Test", "type"=>"OTHER", "description"=>"a FIXED dose meal that will be 900 kcal of a liquid meal", "armGroupLabels"=>["1"]}, {"name"=>"Adjusted Mixed Meal Test", "type"=>"OTHER", "description"=>"a body weight ADJUSTED dose liquid meal.\n\n(30% of total daily energy requirements)", "armGroupLabels"=>["2"]}]}, "contactsLocationsModule"=>{"locations"=>[{"zip"=>"85014", "city"=>"Phoenix", "state"=>"Arizona", "status"=>"RECRUITING", "country"=>"United States", "contacts"=>[{"name"=>"Susi Votruba, Ph.D.", "role"=>"CONTACT", "email"=>"votrubas@niddk.nih.gov", "phone"=>"602-200-5336"}], "facility"=>"NIDDK, Phoenix", "geoPoint"=>{"lat"=>33.44838, "lon"=>-112.07404}}], "centralContacts"=>[{"name"=>"Susi M Votruba, Ph.D.", "role"=>"CONTACT", "email"=>"votrubas@niddk.nih.gov", "phone"=>"(602) 200-5336"}], "overallOfficials"=>[{"name"=>"Susi M Votruba, Ph.D.", "role"=>"PRINCIPAL_INVESTIGATOR", "affiliation"=>"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)"}]}, "ipdSharingStatementModule"=>{"ipdSharing"=>"NO"}, "sponsorCollaboratorsModule"=>{"leadSponsor"=>{"name"=>"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)", "class"=>"NIH"}, "responsibleParty"=>{"type"=>"SPONSOR"}}}}
