Search / Trial NCT06223984

Combined Use of Immunoglobulin and Pulse Steroid Therapies in Severe Covid-19 Patients

Launched by KONYA CITY HOSPITAL · Jan 23, 2024

Trial Information

Current as of October 08, 2024

Completed

Keywords

Description

In December 2019, SARS-COV-2 was isolated from patients for the first time . It then rapidly turned into a pandemic affecting the whole world.While most Covid patients survive the disease with mild symptoms, some may develop severe organ failure and respiratory failure requiring mechanical ventilation . COVİD-19 pneumonia may progress into acute respiratory distress syndrome (ARDS) , diffuse alveolar damage, and vascular endothelitis, which is comlicated with trombosis and hemorrhage. . The most important reason for this has been shown in studies; is thought to be because a group of patien...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * Adult patients with 2019-ncov infection confirmed by PCR;
  • * Absolute value of lymphocytes \< 0. 6x 109/L;
  • * Brescia-COVID respiratory severity scale (BCRSS) score ≥3
  • * Hyperinflammation (defined as elevation of C-reactive protein (CRP) ≥50 mg/L or ferritin ≥500 ng/ ml)
  • * Severe respiratory failure within 48 hours and requires admission to ICU. (severe respiratory failure was defined as PaO2/FiO2 \< 300 mmHg and was supported by positive pressure mechanical ventilation (including non-invasive and invasive mechanical ventilation, PEEP\>=5cmH2O))
  • Exclusion Criteria:
  • * Age \< 18
  • * Pregnant
  • * Allergic to experimental drugs
  • * The underlying disease is very serious and the expected survival time is less than 6 months (such as advanced malignant tumor);
  • * COPD or end-stage lung disease requires home oxygen therapy
  • * Expected survival time not exceeding 48 hours
  • * Autoimmune diseases

About Konya City Hospital

Konya City Hospital is a leading healthcare institution dedicated to advancing medical research and improving patient outcomes through innovative clinical trials. With a commitment to excellence in patient care and a focus on collaborative research, the hospital integrates state-of-the-art facilities and a multidisciplinary team of experienced professionals. By participating in clinical trials, Konya City Hospital aims to contribute to the development of new therapies and enhance the understanding of various medical conditions, ultimately benefiting both the local community and the broader medical field.

Locations

Konya, , Turkey

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0