Search / Trial NCT06224062

Virus and Bronchial Epithelium in Children and the Elderly

Launched by UNIVERSITY HOSPITAL, BORDEAUX · Jan 24, 2024

Trial Information

Current as of October 08, 2024

Recruiting

Keywords

Adenovirus Sars Cov 2 Rhinovirus Children Elderly

Description

The objective of the VIRCHILLD project is to identify age-related modifications of the bronchial epithelium physiology able to explain differences in the response to respiratory viruses. Several epidemiological and cell-based data have demonstrated that respiratory virus infections differentially affect children, adults or the elderly populations. Perhaps, this difference has been put most notably into the spotlight by the current worldwide pandemic of SARS-CoV-2 with a large part of the deaths occurring in the elderly population whereas very few deaths amongst children have been recorded. ...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • For pediatric patients requiring research-specific bronchial brushing:
  • * Child under 18 years old,
  • * Requiring bronchoscopy as part of routine care
  • * Having informed and signed consent from the holders of parental authority
  • For pediatric patients whose bronchial brushing will be carried out as part of their care and for those whose surgical waste will be collected for research:
  • * Child under 18 years old,
  • * Requiring as part of routine care bronchoscopy and brushing or bronchial fibroscopy under general anesthesia or surgical resection/lobectomy
  • * Having expressed their non-opposition to their child's participation in research
  • For adult patients:
  • * Man or woman
  • * Aged 18 or over
  • * Requiring as part of the care, thoracic surgery such as lobectomy, pneumonectomy or lung transplantation in the Thoracic Surgery Department of Haut Lévêque du Chu Hospital in Bordeaux or inclusion in the TUBE study, described below.
  • * having received an information note and not having objected to their participation in the research
  • Exclusion Criteria:
  • * No affiliation or non-beneficiary of a social security system
  • * During a period of relative exclusion compared to another protocol
  • * Patient born before 36 weeks of amenorrhea
  • * Patient with a documented history of pulmonary fibrosis, primary pulmonary hypertension, cystic fibrosis, pulmonary malformation or chronic viral infections (hepatitis, HIV).
  • * Patient with any dental, nasopharyngeal or bronchial infection with fever (\> 38°C) requiring systemic antibiotics in the previous 4 weeks

About University Hospital, Bordeaux

The University Hospital of Bordeaux is a leading academic medical center dedicated to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, the institution integrates cutting-edge scientific inquiry with patient care, fostering an environment that encourages collaboration among multidisciplinary teams. With a commitment to improving treatment outcomes and enhancing patient safety, the University Hospital of Bordeaux plays a pivotal role in the development of new therapies and medical technologies, contributing significantly to the global medical community.

Locations

Bordeaux, , France

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0