Coloured-light in Retinitis Pigmentosa.

Launched by UNIVERSITY COLLEGE, LONDON · Jan 24, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring how different colors of light can affect color vision in adults with a condition called retinitis pigmentosa (RP), which affects how well people can see. If you are over 18 years old and have been genetically diagnosed with RP, you might be eligible to participate. To qualify, you should have a certain level of vision and specific eye structures that are still intact.

During the study, participants will have their vision tested at the beginning and end of the trial. You will randomly receive one of two colored-light torches to use at home for three minutes each morning for 28 days. This means you won’t know which color you are using, and neither will the study team. The trial aims to see if using these colored lights can improve color vision in people with RP. The study is not yet recruiting participants, but it’s an exciting opportunity to help researchers learn more about how light can impact vision in this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Over 18 years old
• • Typical RP where the underlying genetic cause is known. This may include PRPF31, PRPF8, SNRNP200, RHO, RP1 \[autosomal dominant\] and USH2A, EYS \[autosomal recessive\]
• • VA of 0.30 LogMAR (6/12) or better in the study eye
• • Preserved foveal structure defined by intact outer retinal (ellipsoid zone) at the fovea on Optical Coherence Tomography (OCT) and a hyperfluorescent ring within the temporal vascular arcades on Fundus Autofluorescence (FAF) in the study eye
• • Willing and able to provide written informed consent
• Exclusion Criteria:
• • Co-existing ocular pathology will be excluded; however, participants with macular oedema, a common pre-symptomatic manifestation of foveal involvement, will not be excluded
• • Concurrent and/or recent involvement in other research that is likely to interfere with the intervention within 6 months of study enrolment
• • Unwilling or able to provide written informed consent.