Search / Trial NCT06225050

M-2018-334 in Hematological Malignancies

Launched by MILTENYI BIOMEDICINE GMBH · Jan 15, 2024

Trial Information

Current as of October 03, 2024

Not yet recruiting

Keywords

Description

No description provided

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * Patients, between 18 years to 75 years of age, with high-risk hematological malignancy requiring an allogeneic hematopoietic stem cell transplantation (AlloHCT), but do not have an HLA-matched donor available
  • Exclusion Criteria:
  • * \<3 months after preceding autologous transplantation or prior AlloHCT
  • * History of neurological impairment (active seizures, severe peripheral neuropathy, signs of leukoencephalopathy, active CNS infection)
  • * Active fungal infections with radiological and clinical progression
  • * Liver function abnormalities with bilirubin \>2 mg/dL and elevation of transaminases higher than 400 U/L
  • * Chronic active viral hepatitis
  • * Cardiac dysfunction: adult patients ejection fraction \<50% on echocardiography
  • * Patients with uncontrolled, \>grade II hypertension (per Common Toxicity Criteria, CTC)
  • * Creatinine clearance \<60 mL/min/1.73m2
  • * Respiratory failure necessitating supplemental oxygen
  • * HIV infection
  • * Positive anti-donor HLA antibody
  • * Treatment with checkpoint inhibitors in the period between 3 months prior to and 3 months after transplantation
  • * Female patients who are pregnant or breast feeding, or adults of reproductive potential not willing to use an effective method of birth control during study treatment and for at least 12 months thereafter. Note: Women of childbearing potential must have a negative serum pregnancy test at study entry
  • * Concurrent severe or uncontrolled medical disease (e.g., uncontrolled diabetes, myocardial infarction within 6 months prior to the study) which by assessment of the treating physician could compromise participation in the study
  • * Patients with a history of psychiatric illness or a condition which could interfere with their ability to understand the requirements of the study (this includes alcoholism/drug addiction).
  • * Patients unwilling or unable to comply with the protocol or unable to give informed consent
  • * Treatment with any investigational product within 4 weeks prior to study treatment

About Sponsor

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0