Search / Trial NCT06225960

Dorsal Root Ganglion Stimulation in Postherpetic Neuropathy

Launched by ISTITUTI CLINICI SCIENTIFICI MAUGERI SPA · Jan 17, 2024

Trial Information

Current as of October 07, 2024

Enrolling by invitation

Keywords

Postherpetic Neuralgia, Dorsal Root Ganglion Stimulation,

Description

During the manifestation of varicella, the varicella-zoster virus (VZV) localizes in the ganglia of dorsal roots or cranial nerves and remains latent until it can reactivate in conditions of reduced immunity, such as old age or certain diseases. Infection control is linked to cell-mediated immunity, which tends to decrease with age but can be periodically stimulated by exposure to chickenpox or silent reactivations.. Epidemiological studies demonstrate that herpes zoster affects 5.23 cases per 1000 persons/year, with 13.7% showing signs of postherpetic neuralgia (PHN) after three months. I...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:•
  • * Subjects of both genders aged between 18 and 75 years;
  • * Patients with postherpetic neuralgia (PHN) for at least 6 months who have tried the topical and systemic pharmacological therapies recommended in the neuropathic pain guidelines
  • * Distribution of neuropathic pain in a region between C6 and L5;
  • * Individuals capable of adequately adhering to the study protocol and responding to the administered questionnaires;
  • * Signed informed consent.
  • Exclusion Criteria:
  • * Subjects with a history of major depression or other psychiatric conditions that, in the investigator's opinion, may interfere with study participation;
  • * Patients in presumed/confirmed pregnancy;
  • * Patients for whom the placement of spinal/ganglion stimulation systems is contraindicated due to systemic pathological conditions.

About Istituti Clinici Scientifici Maugeri Spa

Istituti Clinici Scientifici Maugeri S.p.A. is a prestigious Italian healthcare organization dedicated to advancing medical research and clinical practice. With a strong focus on patient-centered care, the institution integrates innovative clinical trials into its comprehensive services, fostering collaboration between researchers and healthcare professionals. Known for its commitment to high-quality standards and ethical practices, Istituti Clinici Scientifici Maugeri S.p.A. plays a pivotal role in the development of new therapies and treatment modalities, contributing significantly to the global medical community and enhancing patient outcomes.

Locations

Pavia, , Italy

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0