Search / Trial NCT06226402

Effect of Nebulized and Intravenous Hypertonic Saline 3% on the Management of Patients With Acute Respiratory Distress Syndrome

Launched by TANTA UNIVERSITY · Jan 17, 2024

Trial Information

Current as of October 08, 2024

Recruiting

Keywords

Description

Acute Respiratory Distress Syndrome (ARDS) is a life threatening form of respiratory failure, characterized by acute, diffuse, inflammatory lung injury that results in increased alveolar capillary permeability and the development of non-hydrostatic pulmonary edema. Clinically, ARDS manifests as marked hypoxemia and respiratory distress; patients often progress to respiratory failure that requires invasive mechanical ventilation in the intensive care unit. No specific pharmacological treatment is available for ARDS, which is associated with high morbidity and mortality. The mainstay of the...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * Age from 21 to 60 years old.
  • * Both sexes.
  • * Patients with mild and moderate ARDS whose PaO2/FiO2 ratio ≥ 150 according to the Berlin definition of Acute Respiratory Distress Syndrome.
  • Exclusion Criteria:
  • * Refusal to participate in the study.
  • * Malignancy.
  • * Patients on chemotherapy.
  • * Decompensated renal, hepatic and cardiac disease.
  • * Patients with hypernatremia whose serum Na above 155 mEq/L.
  • * Patients with ARDS whose PaO2/FiO2 ratio \> 150.

About Tanta University

Tanta University is a prestigious academic institution located in Egypt, dedicated to advancing medical research and education. As a clinical trial sponsor, Tanta University leverages its extensive resources and expertise to conduct innovative research initiatives aimed at improving health outcomes. The university collaborates with a network of healthcare professionals, researchers, and institutions to facilitate rigorous clinical trials across various medical disciplines. Committed to ethical standards and scientific integrity, Tanta University strives to contribute to the global body of knowledge while fostering the next generation of medical professionals.

Locations

Tanta, El Gharbia, Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0