Search / Trial NCT06226441

Aminoglycoside Administration in Septic Patients

Launched by UNIVERSITY OF THESSALY · Jan 17, 2024

Trial Information

Current as of October 08, 2024

Recruiting

Keywords

Description

Sepsis is one of the leading causes of ICU mortality and morbidity. Globally, the first place in the list of responsible microorganisms appears to be occupied by multidrug-resistant gram-negative microorganisms (Escherichia Coli, Klebsiella pneumoniae, Pseudomonas aeruginosa και Acinetobacter baumannii). In the quiver of antibiotics we have against them, aminoglycosides (amikacin, gentamicin, tobramycin) have been particularly effective, either as monotherapy or in combination with other antibiotics, e.g. β-lactams. These are bactericidal antibiotics whose action depends on the concentratio...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * age \>18 years
  • * diagnosis of sepsis or septic shock based on established criteria (Sepsis-3) 29
  • * patients with GFR \<40 ml/min
  • * microbiemia from a Gram-negative microorganism and for which the attending physician decides to receive an aminoglycoside or sepsis/septic shock for which it is decided to administer it
  • * signed consent of the patients' next of kin
  • Exclusion Criteria:
  • * absence of consent
  • * known allergic reaction to aminoglycosides
  • * infection from strains resistant to aminoglycosides. As long as the patient has received an aminoglycoside (empirical regimen) and the antibiogram follows it, the treatment can be modified based on the judgment of the attending physician, but the patient's data for the time he received the treatment under consideration are recorded and evaluated
  • * unattainable placement of a central venous line for renal replacement therapy

About University Of Thessaly

The University of Thessaly is a distinguished academic institution located in Greece, recognized for its commitment to advancing medical research and education. With a strong emphasis on interdisciplinary collaboration, the university actively engages in clinical trials aimed at improving healthcare outcomes and fostering innovation in medical practices. Its dedicated research teams, equipped with state-of-the-art facilities and expertise across various fields, strive to contribute valuable insights to the scientific community while prioritizing patient safety and ethical standards in all clinical endeavors.

Locations

Larissa, Thessaly, Greece

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0