Effect of Lidocaine Sprayed for Attenuating Hemodynamic Response During Laryngoscopy and Intubation

Launched by KHON KAEN UNIVERSITY · Jan 23, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how effective a medication called lidocaine is when sprayed directly into the throat area (laryngeal inlet) compared to lidocaine given through an IV (intravenous) line. The goal is to see which method better helps control heart rate and blood pressure during procedures where a tube is placed into the windpipe (intubation) in patients having brain surgery under general anesthesia. Researchers want to find out if the spray method is better at keeping these vital signs steady during the process.

To participate in this study, individuals need to be between 18 and 65 years old and in generally good health (classified as ASA I-II). However, those with certain conditions, such as allergies to lidocaine, difficult airways, or specific underlying health issues (like heart disease or severe kidney problems), will not be eligible. Participants will be randomly assigned to receive either the lidocaine spray or the IV lidocaine, and they can expect to be monitored closely during their procedure to see how well their body responds to each treatment method.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age 18-65 years old
• • 2. American Society of Anesthesiologists (ASA) physical status classification I-II
• Exclusion Criteria:
• • 1. History of lidocaine allergy
• • 2. Predicted difficult airways
• • 3. Body mass index \> 35 kilograms per meter squared
• • 4. Risk aspiration
• • 5. Baseline hemodynamic instability; heart rate \< 50 bpm, heart rate \> 120 bpm, blood pressure \< 90/60 mmHg, blood pressure \> 160/90 mmHg
• • 6. Underlying disease: epilepsy, cardiovascular disease, heart failure, impaired cardiac function, severe renal dysfunction, impaired hepatic function, peripheral vascular disease
• • 7. Pregnancy
• • 8. Cerebral aneurysm, Arteriovenous malformation, Tumor size \> 4 centimeters, Brain herniation