Search / Trial NCT06228872

"Cognitive Rehabilitation With Direct Current Transcranial Stimulation in Post-Traumatic Brain Injury Patients"

Launched by MUTUAL DE SEGURIDAD HOSPITAL CLINICO · Jan 24, 2024

Trial Information

Current as of October 07, 2024

Recruiting

Keywords

Transcranial Direct Current Stimulation (T Dcs) Computerized Cognitive Training (Cct) Traumatic Brain Injury (Tbi) Cognitive Impairment

Description

Introduction: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that can modulate neuronal excitability and enhance neuroplasticity. On the other hand, computerized cognitive training (CCT) therapy uses computers to improve cognitive domains through repeated practice of theoretically-driven skills and strategies. So far, the isolated use of tDCS and its combination with CCT have been explored in the cognitive recovery of patients with traumatic brain injury (TBI), yielding promising results. However, none of the studies to date have investigated the ...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * Age between 18-65 years.
  • * Moderate to severe traumatic brain injury (TBI) according to classification 58 (see Table 3) with a duration of 6 to 12 months.
  • * Minimum of 8 years of education (completed basic education with literacy skills).
  • * Meeting diagnostic criteria (see Table 3) for mild or major cognitive impairment according to the Diagnostic and Statistical Manual of Mental Disorders (DSM).
  • * Capacity to make decisions and understand relevant information regarding participation in a clinical trial, assessed using the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR) 60.
  • * Inclusion of patients with chronic TBI (defined for this study as more than 6 months of duration) based on the proposed mechanism of chronic TBI involving decreased cerebral neuroplasticity, leading to long-term cognitive dysfunction and functional limitations 62. Transcranial Direct Current Stimulation (tDCS) has shown effectiveness in enhancing neuroplasticity in various neurological and psychiatric conditions 63.
  • Exclusion Criteria:
  • * History of cognitive impairment unrelated to post-traumatic causes (for which the patient is being treated at Mutual de Seguridad).
  • * History of epileptic seizures.
  • * Pre-existing neuropsychiatric disorders.
  • * Presence of metallic objects in the body such as aneurysm implants, hemostatic clips, implanted electrodes, and electrical devices like pacemakers.

About Mutual De Seguridad Hospital Clinico

Mutual de Seguridad Hospital Clínico is a leading healthcare institution dedicated to advancing medical research and improving patient outcomes through innovative clinical trials. With a strong emphasis on patient safety and ethical standards, the hospital integrates cutting-edge technology and a multidisciplinary approach to provide comprehensive care. Its commitment to scientific excellence and collaboration with healthcare professionals positions it as a pivotal player in the field of clinical research, fostering advancements in treatment modalities and enhancing the overall quality of healthcare delivery.

Locations

Santiago, Metropolitan Region, Chile

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0