Search / Trial NCT06229509

Study of the Cytokine Response During Exercise Dyspnea in Patients With Chronic Obstructive Pulmonary Disease (COPD). Effect of Body Composition

Launched by UNIVERSITY HOSPITAL, CLERMONT-FERRAND · Jan 19, 2024

Trial Information

Current as of October 08, 2024

Not yet recruiting

Keywords

Cytokines Myokines Adipokines Exercise Noninvasive Ventilation Sarcopenia

Description

No description provided

Gender

MALE

Eligibility criteria

  • Inclusion Criteria:
  • * Age ≥ 18 years
  • * Patient affiliated to a social security scheme.
  • * Patient capable of giving free, informed, written and signed consent.
  • * Male gender
  • * Severe COPD (Chronic Obstructive Pulmonary Disease) diagnosed according to GOLD criteria, in a stable state, with a forced expiratory volume (FEV1) from 30 to 50% of the predicted value (measured within one year during respiratory function tests (RFT)
  • * History of smoking \>10 pack-years with cessation of smoking for more than 12 months.
  • * Patient judged by the investigator to be able to tolerate inspiratory pressure during a preliminary cycling exercise test.
  • Exclusion Criteria:
  • * Severe anxiety disorders, assessed by the STAY Y-B form questionnaire; a score above 65 indicates very high day-to-day anxiety.
  • * Patient under guardianship/trusteeship/supervision of justice
  • * Chronic hypercapnia at rest (CO2 arterial pressure ≥ 50mmHg)
  • * Chronic use of non-invasive ventilation
  • * Known pulmonary hypertension
  • * Chronic administration of oral corticosteroids
  • * Unstable heart disease

About University Hospital, Clermont Ferrand

The University Hospital of Clermont-Ferrand is a leading academic medical institution dedicated to advancing healthcare through innovative research and clinical trials. Renowned for its multidisciplinary approach, the hospital integrates cutting-edge scientific inquiry with patient care, fostering an environment that promotes collaboration among healthcare professionals, researchers, and academic partners. With a strong commitment to improving patient outcomes, the institution actively engages in a wide array of clinical studies, ranging from early-phase trials to large-scale interventions, aimed at addressing critical health challenges and enhancing treatment modalities. Its state-of-the-art facilities and expertise make it a pivotal contributor to clinical research in the region and beyond.

Locations

Clermont Ferrand, , France

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0