Search / Trial NCT06229626

Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Jan 19, 2024

Trial Information

Current as of December 21, 2024

Recruiting

Keywords

Physical Rehabilitation Program Hereditary Spastic Paraparesis

ClinConnect Summary

The Walk-up study is looking at how an intensive physical training program can help people with hereditary spastic paraparesis, a condition that affects movement due to inherited nerve problems. This study aims to see if this training can make walking easier for patients, especially since current treatments only focus on managing symptoms. Participants will be divided into two groups: one will receive the training while the other will act as a control group to help researchers compare results.

To join the study, patients need to have a confirmed genetic diagnosis of hereditary spastic paraparesis and be able to walk for six minutes with some support, like a cane or walker. They should also be receiving physiotherapy regularly and have internet access to use additional training materials. It's important to note that patients who have had certain treatments recently or are involved in other research studies might not be eligible. Participants can expect to engage in regular training sessions and contribute to valuable research that could improve treatments for their condition.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patient with molecular diagnosis of hereditary spastic paraparesis based on pathogenic variant of SPAST gene,
  • Walking possible for 6 minutes without human assistance (one or more technical aids are authorized: e.g. cane, walker, orthoses),
  • At least 1 physiotherapy session per week already in place.
  • Understanding of the protocol
  • Possibility of connecting to the Internet from home to access video material provided as part of the protocol.
  • Exclusion Criteria:
  • Botulinum toxin injection within 2 months of protocol inclusion
  • Discontinuation of private physiotherapy,
  • Refusal to participate in the protocol,
  • Participation in another interventional clinical trial evaluating a health product or in a randomized clinical trial
  • Pregnant women
  • Not affiliated to a social security scheme or beneficiary of such a scheme
  • Patient under guardianship or trusteeship

About Assistance Publique Hôpitaux De Paris

Assistance Publique - Hôpitaux de Paris (AP-HP) is a leading public hospital system in France, renowned for its commitment to healthcare excellence and innovative medical research. As a prominent clinical trial sponsor, AP-HP plays a pivotal role in advancing medical knowledge and improving patient care through rigorous scientific investigations across a wide range of therapeutic areas. With a focus on collaboration and interdisciplinary approaches, AP-HP leverages its extensive network of hospitals and expert clinicians to facilitate high-quality clinical trials that adhere to the highest ethical and regulatory standards, ultimately aiming to translate research findings into tangible health benefits for diverse patient populations.

Locations

Paris, , France

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0