Search / Trial NCT06229652

Stress Management in Depressive Disorder: Resilience Training vs. Yoga: Biological, Epigenetic, and Brain Correlates

Launched by MEDICAL UNIVERSITY INNSBRUCK · Jan 26, 2024

Trial Information

Current as of October 09, 2024

Not yet recruiting

Keywords

Depression Stress Management Coping Resilience Yoga

Description

The aim of this clinical trial is to evaluate the effects of a Resilience and Stress Management Intervention Program (RASMUS) compared with yoga on stress perception, coping strategies, depressive symptoms, anxiety, resilience and quality of life in people diagnosed with major depressive disorder (MDD) in the short and long term. In addition to psychological factors, biological parameters will be examined to define biomarkers involved in stress response. In the optional neuroimaging part, the effects of the planned interventions on the structure, metabolism and function of the brain will b...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * Confirmed diagnosis of MDD,
  • * Outpatient care for at least 3 months,
  • * Ongoing psychopharmacological treatment,
  • * Age between 18 and 65 years,
  • * Knowledge of written and spoken German,
  • * MADRS score ≤ 34 (moderate severity of symptoms),
  • * Written informed consent.
  • Exclusion Criteria:
  • * Other Axis I psychiatric disorder (organic mental disorders, psychoactive substance use \[excl. caffeine and nicotine abuse\], schizophrenia, bipolar disorder, neurotic disorders \[excl. anxiety disorders\], eating disorders, acute suicidality)
  • * Severe somatic illnesses,
  • * Pregnancy/breastfeeding,
  • * Undertaking regular yoga practice (more than once per week) over the past 3 months,
  • * Current use of psychotherapy.
  • Further exclusion criteria for the neuroimaging sub-study:
  • * History of neurological trauma or trauma to the central nervous system,
  • * MRI contraindications (claustrophobia, metallic, electrical, magnetic or mechanically driven implants, tattoos on the head or neck or other clinically relevant contraindications)
  • * Positive drug urine test.

About Medical University Innsbruck

The Medical University of Innsbruck is a leading academic institution dedicated to advancing healthcare through innovative research and clinical excellence. Situated in the heart of the Austrian Alps, it combines a rich tradition of medical education with cutting-edge scientific inquiry. As a prominent sponsor of clinical trials, the university focuses on a broad spectrum of medical fields, emphasizing the translation of research findings into practical applications for patient care. With a commitment to ethical standards and rigorous methodologies, the Medical University of Innsbruck strives to enhance treatment options and improve health outcomes globally through its collaborative efforts in clinical research.

Locations

Innsbruck, Tirol, Austria

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0