Search / Trial NCT06230198

The Effect of Retrograde Autologous Priming on Transfusion Requirements After Cardiac Surgery

Launched by POPULATION HEALTH RESEARCH INSTITUTE · Jan 18, 2024

Trial Information

Current as of December 30, 2024

Not yet recruiting

Keywords

ClinConnect Summary

About 50% of patients undergoing cardiac surgery require red blood cell (RBC) transfusion. Given the limited blood supply and harms of transfusion, evidence-based blood conservation strategies are a priority. There is one such simple conservation technique called Retrograde autologous priming (RAP), in which the patient's own blood, rather than crystalloid fluid, is used to prime the heart-lung machine. Ultimately, it minimizes the loss of RBCs during surgery. Despite evidence of RAP reducing incidence of RBC transfusions by 40% and RBC units transfused by 38% in small randomized trials, it...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Hospitals completing \>200 adult cardiac surgical cases a year; (ii) 95% of cardiovascular surgery group (i.e., cardiac anesthesiologists, surgeons, and perfusionists) agree to manage patients under both autologous priming policies as per their randomization schedule for the duration of the trial.
  • All patients undergoing cardiac surgery on cardiopulmonary bypass at an enrolled site during the trial period will be included in data collection.
  • Exclusion Criteria:
  • Complete \<=200 cardiac surgical cases.
  • \<95% of their cardiovascular surgery group agrees to manage patients according to either of the two policies.

Trial Officials

Jessica Spence, MD, PhD

Principal Investigator

Population Health Research Institute

About Population Health Research Institute

The Population Health Research Institute (PHRI) is a leading clinical research organization dedicated to advancing the understanding of population health through innovative research methodologies. With a focus on large-scale, multi-center clinical trials and epidemiological studies, PHRI aims to address pressing health challenges by investigating the interplay between lifestyle, genetic, and environmental factors. By fostering collaboration among researchers, healthcare providers, and communities, PHRI strives to generate evidence-based insights that inform public health policies and improve health outcomes on a global scale. Their commitment to excellence in research is underscored by a robust infrastructure and a multidisciplinary team of experts dedicated to translating research findings into actionable solutions for diverse populations.

Locations

Montreal, Quebec, Canada

Winnipeg, Manitoba, Canada

Hamilton, Ontario, Canada

Montreal, Quebec, Canada

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0