Clinical Study of Lung Protective Ventilation Strategies and Tumor Microenvironment
Launched by AFFILIATED HOSPITAL OF NANTONG UNIVERSITY · Jan 26, 2024
Trial Information
Current as of July 01, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
This study will be conducted in the Affiliated Hospital of Nantong University. Sixty CRC patients are randomized into traditional ventilation strategy group (control group) and lung protective ventilation strategy group (experimental group), there were 30 cases in each group. The control group adopted conventional ventilation strategies: tidal volume (VT)=10-12 ml/kg, respiratory rate ( f)=12 breaths / minute, positive end expiratory pressure(PEEP)=0 cmH₂O, fraction of inspired oxygen =0.5; the experimental group used lung protective ventilation strategies: tidal volume ( VT)=6-8 ml/kg, f=1...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. pathologic diagnosis of Colorectal Cancer
- • 2. American society of Aneshesiologists(ASA)physical status classification system Grade Ⅱ-Ⅲ;
- • 3. From 51-70 years old with no gender restrictions
- • 4. Normal cardiopulmonary function before operation
- • 5. Body Mass Index:18-30
- Exclusion Criteria:
- • 1. Preoperative anemia (hemoglobin\<10g/dl)
- • 2. Patients with preoperative mechanical ventilation;
- • 3. A history of pulmonary infection and pulmonary tuberculosis within 1 month before surgery;
- • 4. Preoperative blood oxygen saturation (SpO₂) was less than 90% (SpO₂\<90%), or the oxygen partial pressure (PaO₂) was less than 90% (PaO₂\<60 mmHg), or PaO₂/fraction of inspired oxygen(FiO₂)ratio\<300 mmHg, or arterial blood carbon dioxide partial pressure (PaCO₂) was greater than 45 mmHg (PaCO₂\>45 mmHg);
- • 5. Patients who take immunosuppressants, neoadjuvant chemotherapy and radiotherapy before surgery;
- • 6. Preoperative abnormal coagulation function.
About Affiliated Hospital Of Nantong University
The Affiliated Hospital of Nantong University is a leading medical institution dedicated to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, the hospital is committed to enhancing patient care by conducting rigorous studies that align with ethical standards and regulatory requirements. With a strong emphasis on collaboration among multidisciplinary teams, the hospital leverages its state-of-the-art facilities and expert staff to foster groundbreaking research initiatives aimed at improving treatment outcomes and addressing critical health challenges.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Nantong, Jiangsu, China
Patients applied
Trial Officials
Yongtao Gao, Master
Study Director
The Affiliated Hospital of Nantong University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported