Clinical Study of Lung Protective Ventilation Strategies and Tumor Microenvironment

Launched by AFFILIATED HOSPITAL OF NANTONG UNIVERSITY · Jan 26, 2024

Keywords

ClinConnect Summary

This study will be conducted in the Affiliated Hospital of Nantong University. Sixty CRC patients are randomized into traditional ventilation strategy group (control group) and lung protective ventilation strategy group (experimental group), there were 30 cases in each group. The control group adopted conventional ventilation strategies: tidal volume (VT)=10-12 ml/kg, respiratory rate ( f)=12 breaths / minute, positive end expiratory pressure（PEEP）=0 cmH₂O, fraction of inspired oxygen =0.5; the experimental group used lung protective ventilation strategies: tidal volume ( VT)=6-8 ml/kg, f=1...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. pathologic diagnosis of Colorectal Cancer
• • 2. American society of Aneshesiologists（ASA）physical status classification system Grade Ⅱ-Ⅲ;
• • 3. From 51-70 years old with no gender restrictions
• • 4. Normal cardiopulmonary function before operation
• • 5. Body Mass Index:18-30
• Exclusion Criteria:
• • 1. Preoperative anemia (hemoglobin\<10g/dl)
• • 2. Patients with preoperative mechanical ventilation;
• • 3. A history of pulmonary infection and pulmonary tuberculosis within 1 month before surgery;
• • 4. Preoperative blood oxygen saturation (SpO₂) was less than 90% (SpO₂\<90%), or the oxygen partial pressure (PaO₂) was less than 90% (PaO₂\<60 mmHg), or PaO₂/fraction of inspired oxygen（FiO₂）ratio\<300 mmHg, or arterial blood carbon dioxide partial pressure (PaCO₂) was greater than 45 mmHg (PaCO₂\>45 mmHg);
• • 5. Patients who take immunosuppressants, neoadjuvant chemotherapy and radiotherapy before surgery;
• • 6. Preoperative abnormal coagulation function.