Search / Trial NCT06231069

Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults

Launched by MCMASTER UNIVERSITY · Jan 20, 2024

Trial Information

Current as of December 21, 2024

Withdrawn

Keywords

Muscle

ClinConnect Summary

Sedentarism is highly prevalent, world-wide, and predisposes for chronic disease and premature death. Conversely, regular physical activity (PA) protects against cardiovascular disease (CVD), deterioration of the musculoskeletal system, cancer, obesity, type 2 diabetes, depression, anxiety, and neurodegeneration. Similar to most adults in the world, the majority of Canadians are not meeting the minimal PA guidelines, with total health care cost attributed to physical inactivity estimated to be $6.8 billion. Therefore, it is imperative to develop strategies to increase PA rates across the ge...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • non-smoking
  • non-diabetic
  • apparently healthy
  • minimally recreationally active
  • males and females aged 18-30 years
  • Exclusion Criteria:
  • pregnancy
  • breast feeding
  • smoking
  • obesity
  • diabetes mellitus
  • cardiovascular disease (recent myocardial infarction (≤ 6 months)
  • hypertension requiring more than 2 medications
  • congestive heart failure requiring more than one medication,
  • renal disease (creatinine \> 130),
  • previous stroke with residual hemiparesis,
  • active musculoskeletal injuries and/or severe osteoarthritis,
  • significant weight loss in the 3-month period prior to the study,
  • vegan diet,
  • dairy protein allergy,
  • muscular dystrophy,
  • severe peripheral neuropathy,
  • severe osteoporosis,
  • use of medications known to affect protein metabolism (i.e. corticosteroids),
  • inability to consent,
  • chronic obstructive pulmonary disease (FVC or FEV1 \< 70% of age predicted mean value),
  • asthma requiring more than two medications.
  • Subjects on supplements will be considered on a case-by-case basis, but they will be asked to refrain from intake for at least 2 weeks prior to partaking in this study.
  • While adverse events are not anticipated, participants will be asked to disclose if they are using supplements that may have negative/interactive effects with our study products. Each participant's list of medications will also be checked for potential interactive side-effects with our supplements; however, the individual doses have specifically been chosen to be at the low end to minimize the likelihood of such interactions.

Trial Officials

Mark A Tarnopolsky, MD, PhD

Principal Investigator

McMaster University

About Mcmaster University

McMaster University, a leading research institution located in Hamilton, Ontario, Canada, is renowned for its innovative approach to education and its commitment to advancing healthcare through rigorous clinical research. The university's diverse research programs are supported by a multidisciplinary team of experts dedicated to improving patient outcomes and public health. With a strong emphasis on evidence-based medicine, McMaster University actively engages in clinical trials that explore new therapies, interventions, and health technologies, fostering collaboration among researchers, healthcare professionals, and industry partners to translate findings into real-world applications.

Locations

Hamilton, Ontario, Canada

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0