Search / Trial NCT06231251

Endoscopic Gastric Reduction of Gastric Mucosa in Obesity

Launched by ZAGAZIG UNIVERSITY · Jan 19, 2024

Trial Information

Current as of October 09, 2024

Recruiting

Keywords

Description

Ghrelin is 28 amino acid peptide hormone, approximately 70 % of circulating ghrelin is secreted by the stomach, with most of the remainder originating in duodenum, jejunum, and ileum. Lower amount of secretion outside the gut, including hypothalamus (arcuate nucleus and paraventricular nucleus), pituitary, lung, adrenal cortex, kidney, bone, testis, placenta and pancreatic islet cells Ghrelin enhances the secretion of growth hormone, the stimulation of appetite and food intake, the modulation of gastric acid secretion \& motility and the endocrine and exocrine pancreatic secretions. Synthet...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * body mass index more than 25
  • * diagnosis of diabetes mellitus.
  • * diagnosis of cardio-metabolic syndrome.
  • * fatty liver disease diagnosed by abdominal ultrasound.
  • Exclusion Criteria:
  • * use of drugs which induce insulin resistance, diabetes and hepatic steatosis.
  • * excess alcohol consumption.
  • * chronic gastritis, active peptic ulcer.
  • * malignancy.
  • * depression and severe psychological disorders
  • * inability to give informed consent.
  • * coagulopathy (INR more than 1.5, platelets less than 50000 per cmm).
  • * severe cardiopulmonary comorbidity.

About Zagazig University

Zagazig University, a prominent educational and research institution located in Egypt, plays a pivotal role in advancing medical knowledge and promoting health innovations through its clinical trials. With a commitment to excellence in research, the university leverages its diverse expertise and state-of-the-art facilities to conduct rigorous clinical studies that aim to improve patient care and outcomes. By fostering collaboration among multidisciplinary teams, Zagazig University contributes significantly to the global medical community, ensuring that its clinical trials adhere to the highest ethical standards and regulatory requirements.

Locations

Zagazig, Sharkia, Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0