Search / Trial NCT06232369

Threat Reversal Abnormality in Patients With Anxiety Disorders

Launched by SHENZHEN KANGNING HOSPITAL · Jan 28, 2024

Trial Information

Current as of October 09, 2024

Not yet recruiting

Keywords

Threat Reversal Emotion Flexibility

Description

In this study, there are three sub-trials in combination with skin conductance response (SCR), functional magnetic resonance imaging (fMRI), and non-invasive neuromodulation techniques to uncover the abnormal threat reversal in anxiety disorder at behavioral and neural levels. Participants in the first trial will learn the threat of emotional faces based on the Pavlovian conditioned fear learning paradigm; their neural activities in the hypothesized brain regions will be obtained via brain imaging equipment. The researchers will compare the differences among three groups (one patient group...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria for patient participants:
  • Clinical diagnosis of anxiety disorders (by psychiatrists using the structured clinical interview for DSM-IV-TR (SCID) with reference to the diagnostic criteria for GAD according to the ICD-10)
  • Exclusion Criteria for patient participants:
  • 1. A history of serious cardiovascular, cerebrovascular diseases, stroke, or other neurological disorders, a history of gastrointestinal diseases.
  • 2. Severe hearing or vision impairments.
  • 3. Metallic implants in the body, such as non-removable dentures, stents, metal plates, joint metal replacements, etc.
  • 4. Claustrophobia.
  • 5. Acute or chronic diseases or infections.
  • 6. Pregnancy or breastfeeding.
  • 7. Smoking or drinking alcohol within 24 hours before the experiment.
  • 8. Previous participation in similar experiments conducted by this institution.
  • Inclusion Criteria for healthy control participants:
  • 1. No physical diseases or mental disorders.
  • 2. No claustrophobia.
  • 3. No hereditary diseases.
  • 4. No medication history or smoking history.
  • 5. Females not pregnant and not in their menstrual period.
  • 6. Normal vision or corrected vision, no smoking, drinking alcohol, or taking medication within 24 hours prior to the experiment.
  • 7. No previous participation in similar experiments.

About Shenzhen Kangning Hospital

Shenzhen Kangning Hospital is a leading medical institution dedicated to advancing healthcare through innovative research and clinical trials. Located in Shenzhen, China, the hospital specializes in mental health and neurological disorders, offering comprehensive services that integrate patient care with groundbreaking scientific inquiry. With a commitment to improving treatment outcomes, Shenzhen Kangning Hospital collaborates with a network of healthcare professionals and researchers to conduct rigorous clinical trials that adhere to the highest ethical standards and regulatory guidelines. Its state-of-the-art facilities and multidisciplinary approach ensure a robust environment for both patient safety and the advancement of medical knowledge.

Locations

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Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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