Molecular Analysis for Precision Surgery in Thyroid Cancer Trial
Launched by UNIVERSITY OF CALIFORNIA, LOS ANGELES · Jan 29, 2024
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
The Molecular Analysis for Precision Surgery in Thyroid Cancer Trial is studying the best surgical approach for patients with papillary thyroid cancer, particularly those with intermediate-risk tumors. This study aims to see if using molecular analysis (a test that looks at the genes in the cancer cells) can help doctors decide whether a patient needs a partial thyroid removal (lobectomy) or a total removal (thyroidectomy). Patients who meet specific criteria, such as being 18 years or older and having certain types of thyroid nodules, may be eligible to participate in this trial.
Participants can expect to undergo a preoperative molecular analysis, and if they fall into the intermediate-risk category, they will be randomly assigned to either surgery option. The researchers hope that at least half of the eligible patients will agree to participate and follow through with the randomization process. This study is crucial because it could lead to better, more personalized treatment options for patients with thyroid cancer in the future.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients aged 18 years or older at the time of enrollment
- • English-speaking
- • Bethesda V or VI thyroid nodule that are 1-4cm in size
- • Bethesda III or IV nodules who underwent previously underwent Thyroseq molecular analysis that returned with intermediate molecular risk disease
- Exclusion Criteria:
- • Prior thyroid operation
- • Extrathyroidal extension or lymph node metastases seen on ultrasound
- • Distant metastatic disease
About University Of California, Los Angeles
The University of California, Los Angeles (UCLA) is a prestigious academic institution renowned for its commitment to research and innovation in the biomedical field. As a clinical trial sponsor, UCLA leverages its cutting-edge facilities, expert faculty, and collaborative environment to advance medical knowledge and improve patient care. The university is dedicated to conducting rigorous clinical research that adheres to the highest ethical standards, aiming to translate scientific discoveries into effective therapies and interventions. Through its diverse array of clinical trials, UCLA seeks to address critical health challenges while fostering the development of future healthcare leaders.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Los Angeles, California, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported