Search / Trial NCT06236165

Clinical Study Evaluating Efficacy, Safety and Molecular Mechanism of Both N-acetylcysteine and Pentoxifylline Supplementation in Patients With Hepatic and Post Hepatic Jaundice

Launched by TANTA UNIVERSITY · Jan 24, 2024

Trial Information

Current as of December 21, 2024

Recruiting

Keywords

Jaundice, N Acetylcysteine, Pentoxifylline

ClinConnect Summary

This clinical trial is studying two medications, N-acetylcysteine and Pentoxifylline, to see if they can help improve liver function and reduce jaundice in patients. Jaundice is a condition where the skin and eyes turn yellow due to high levels of a substance called bilirubin in the blood. The trial aims to determine how effective and safe these supplements are for patients with hepatic (liver-related) and post-hepatic (after liver issues) jaundice.

To participate in this study, you need to be between 18 and 70 years old and have been diagnosed with jaundice, specifically with a direct bilirubin level of 3 mg/dL or higher. However, there are some important exclusions, like being pregnant or nursing, having certain liver conditions, or a history of severe allergic reactions to these medications. If eligible, participants will receive either of the supplements and will be monitored to see how their bilirubin levels and liver function improve. This trial is currently recruiting participants and welcomes individuals of any gender.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients age 18-70 years old.
  • Patients diagnosed with jaundice and increased level direct bilirubin ≥ 3 mg/dL.
  • Exclusion Criteria:
  • Pregnancy.
  • Nursing mothers.
  • Patients with increased indirect bilirubin level.
  • Patients who have Gilbert syndrome or Crigler Najjar syndrome.
  • Patients with Child Paugh C score (10-15 point).
  • History of intolerance and hypersensitivity to Pentoxifylline or to xanthine derivatives such as caffeine, theophylline.
  • Recent hemorrhage.
  • Patients who have risk factors potentially complicated by hemorrhage.
  • Taking anticoagulants or antiplatelet therapy.
  • History of known hypersensitivity to N-acetylcysteine.

Trial Officials

Samah Hussein

Principal Investigator

faculty of pharmacy Tanta University

About Tanta University

Tanta University is a prestigious academic institution located in Egypt, dedicated to advancing medical research and education. As a clinical trial sponsor, Tanta University leverages its extensive resources and expertise to conduct innovative research initiatives aimed at improving health outcomes. The university collaborates with a network of healthcare professionals, researchers, and institutions to facilitate rigorous clinical trials across various medical disciplines. Committed to ethical standards and scientific integrity, Tanta University strives to contribute to the global body of knowledge while fostering the next generation of medical professionals.

Locations

Tanta, , Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0