Search / Trial NCT06236464

Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas

Launched by NATIONAL CANCER INSTITUTE, NAPLES · Jan 24, 2024

Trial Information

Current as of October 07, 2024

Recruiting

Keywords

Description

This is a multicentric, retrospective, and prospective biomarker study, involving a total of 170 patients with SCC (Squamous Cell Carcinoma) of the mucosa of the anogenital tract and head-neck region, recruited from INT-NA (n=50), UPO (n=40), AOUP (n=40), and ITB (n=40). Specifically, retrospective and prospective samples will be collected and analyzed for the study of molecular and viral biomarkers. Simultaneously, fibroblastic tumor-associated cells (CAFs) will be isolated from prospective samples. Through co-cultivation with immortalized cell lines derived from anogenital and head-neck S...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients aged ≥ 18 years, candidates for surgical treatment for squamous cell carcinoma of the anus, uterine cervix, vulva, and head-neck region (including microinvasive and invasive carcinomas) who are capable of understanding and willing to sign the informed consent form. Prospective patients must provide written informed consent before any procedures.
  • Exclusion Criteria:
  • Patients presenting any of the following criteria are not eligible for inclusion in this study. Exclusion criteria include:
  • 1. Metastatic neoplasia
  • 2. Treatment for other oncological pathologies
  • 3. Congenital or acquired immunosuppression (HIV, organ transplant, pharmacological)

About National Cancer Institute, Naples

The National Cancer Institute (NCI) in Naples is a leading research institution dedicated to advancing the understanding and treatment of cancer through innovative clinical trials. As a prominent sponsor of cancer research, the NCI focuses on developing novel therapies, improving patient outcomes, and exploring cutting-edge methodologies in oncology. With a commitment to scientific rigor and collaboration, the NCI in Naples engages in partnerships with academic institutions and healthcare providers to facilitate groundbreaking studies that address critical challenges in cancer care. Their mission is to translate research findings into effective treatments, ultimately enhancing the lives of patients affected by cancer.

Locations

Pisa, , Italy

Pisa, , Italy

Novara, , Italy

Bari, , Italy

Napoli, , Italy

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0